The preoperative prognostic nutritional index is a predictive and prognostic factor of high-grade serous ovarian cancer
Abstract Background The aim of our study was to investigate whether an inflammation-based prognostic score, the prognostic nutritional index (PNI), was associated with clinical characteristics and prognosis in patients with high-grade serous ovarian cancer (HGSC). Methods We retrospectively investig...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2018-09-01
|
Series: | BMC Cancer |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12885-018-4732-8 |
id |
doaj-97108a55e94e4fbd9e71c0e3d6ce1419 |
---|---|
record_format |
Article |
spelling |
doaj-97108a55e94e4fbd9e71c0e3d6ce14192020-11-24T20:51:32ZengBMCBMC Cancer1471-24072018-09-011811610.1186/s12885-018-4732-8The preoperative prognostic nutritional index is a predictive and prognostic factor of high-grade serous ovarian cancerZheng Feng0Hao Wen1Xingzhu Ju2Rui Bi3Xiaojun Chen4Wentao Yang5Xiaohua Wu6Department of Gynecological Oncology, Fudan University Shanghai Cancer CenterDepartment of Gynecological Oncology, Fudan University Shanghai Cancer CenterDepartment of Gynecological Oncology, Fudan University Shanghai Cancer CenterDepartment of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Gynecological Oncology, Fudan University Shanghai Cancer CenterDepartment of Oncology, Shanghai Medical College, Fudan UniversityDepartment of Gynecological Oncology, Fudan University Shanghai Cancer CenterAbstract Background The aim of our study was to investigate whether an inflammation-based prognostic score, the prognostic nutritional index (PNI), was associated with clinical characteristics and prognosis in patients with high-grade serous ovarian cancer (HGSC). Methods We retrospectively investigated 875 patients who underwent primary staging or debulking surgery for HGSC between April 2005 and June 2013 at our institution. None of these patients received neoadjuvant chemotherapy. Preoperative PNI was calculated as serum albumin (g/L) + 0.005 × lymphocyte count (per mm3). The optimal PNI cutoff value for overall survival (OS) was identified using the online tool “Cutoff Finder”. Clinical characteristics and PNI were compared with chi-square or Fisher’s exact tests, as appropriate. The impact of PNI on OS was analyzed using the Kaplan–Meier method and Cox proportional hazards model. Results The median (range) PNI was 46.2 (29.2–67.7). The 45.45 cutoff value discriminated patients into the high-PNI and low-PNI groups. A low preoperative PNI was associated with an advanced FIGO stage, increased CA125 level, more extensive ascites, residual disease and platinum resistance. For univariate analyses, a high PNI was associated with increased OS (p < 0.001). In multivariate analyses, the PNI remained an independent predictor of OS as a continuous variable (p = 0.021) but not as dichotomized groups (p = 0.346). Conclusion Our study demonstrated that the PNI could be a predictive and prognostic parameter for HGSC.http://link.springer.com/article/10.1186/s12885-018-4732-8Ovarian cancerPrognostic nutritional indexResidual diseasePlatinum sensitivityOverall survival |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zheng Feng Hao Wen Xingzhu Ju Rui Bi Xiaojun Chen Wentao Yang Xiaohua Wu |
spellingShingle |
Zheng Feng Hao Wen Xingzhu Ju Rui Bi Xiaojun Chen Wentao Yang Xiaohua Wu The preoperative prognostic nutritional index is a predictive and prognostic factor of high-grade serous ovarian cancer BMC Cancer Ovarian cancer Prognostic nutritional index Residual disease Platinum sensitivity Overall survival |
author_facet |
Zheng Feng Hao Wen Xingzhu Ju Rui Bi Xiaojun Chen Wentao Yang Xiaohua Wu |
author_sort |
Zheng Feng |
title |
The preoperative prognostic nutritional index is a predictive and prognostic factor of high-grade serous ovarian cancer |
title_short |
The preoperative prognostic nutritional index is a predictive and prognostic factor of high-grade serous ovarian cancer |
title_full |
The preoperative prognostic nutritional index is a predictive and prognostic factor of high-grade serous ovarian cancer |
title_fullStr |
The preoperative prognostic nutritional index is a predictive and prognostic factor of high-grade serous ovarian cancer |
title_full_unstemmed |
The preoperative prognostic nutritional index is a predictive and prognostic factor of high-grade serous ovarian cancer |
title_sort |
preoperative prognostic nutritional index is a predictive and prognostic factor of high-grade serous ovarian cancer |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2018-09-01 |
description |
Abstract Background The aim of our study was to investigate whether an inflammation-based prognostic score, the prognostic nutritional index (PNI), was associated with clinical characteristics and prognosis in patients with high-grade serous ovarian cancer (HGSC). Methods We retrospectively investigated 875 patients who underwent primary staging or debulking surgery for HGSC between April 2005 and June 2013 at our institution. None of these patients received neoadjuvant chemotherapy. Preoperative PNI was calculated as serum albumin (g/L) + 0.005 × lymphocyte count (per mm3). The optimal PNI cutoff value for overall survival (OS) was identified using the online tool “Cutoff Finder”. Clinical characteristics and PNI were compared with chi-square or Fisher’s exact tests, as appropriate. The impact of PNI on OS was analyzed using the Kaplan–Meier method and Cox proportional hazards model. Results The median (range) PNI was 46.2 (29.2–67.7). The 45.45 cutoff value discriminated patients into the high-PNI and low-PNI groups. A low preoperative PNI was associated with an advanced FIGO stage, increased CA125 level, more extensive ascites, residual disease and platinum resistance. For univariate analyses, a high PNI was associated with increased OS (p < 0.001). In multivariate analyses, the PNI remained an independent predictor of OS as a continuous variable (p = 0.021) but not as dichotomized groups (p = 0.346). Conclusion Our study demonstrated that the PNI could be a predictive and prognostic parameter for HGSC. |
topic |
Ovarian cancer Prognostic nutritional index Residual disease Platinum sensitivity Overall survival |
url |
http://link.springer.com/article/10.1186/s12885-018-4732-8 |
work_keys_str_mv |
AT zhengfeng thepreoperativeprognosticnutritionalindexisapredictiveandprognosticfactorofhighgradeserousovariancancer AT haowen thepreoperativeprognosticnutritionalindexisapredictiveandprognosticfactorofhighgradeserousovariancancer AT xingzhuju thepreoperativeprognosticnutritionalindexisapredictiveandprognosticfactorofhighgradeserousovariancancer AT ruibi thepreoperativeprognosticnutritionalindexisapredictiveandprognosticfactorofhighgradeserousovariancancer AT xiaojunchen thepreoperativeprognosticnutritionalindexisapredictiveandprognosticfactorofhighgradeserousovariancancer AT wentaoyang thepreoperativeprognosticnutritionalindexisapredictiveandprognosticfactorofhighgradeserousovariancancer AT xiaohuawu thepreoperativeprognosticnutritionalindexisapredictiveandprognosticfactorofhighgradeserousovariancancer AT zhengfeng preoperativeprognosticnutritionalindexisapredictiveandprognosticfactorofhighgradeserousovariancancer AT haowen preoperativeprognosticnutritionalindexisapredictiveandprognosticfactorofhighgradeserousovariancancer AT xingzhuju preoperativeprognosticnutritionalindexisapredictiveandprognosticfactorofhighgradeserousovariancancer AT ruibi preoperativeprognosticnutritionalindexisapredictiveandprognosticfactorofhighgradeserousovariancancer AT xiaojunchen preoperativeprognosticnutritionalindexisapredictiveandprognosticfactorofhighgradeserousovariancancer AT wentaoyang preoperativeprognosticnutritionalindexisapredictiveandprognosticfactorofhighgradeserousovariancancer AT xiaohuawu preoperativeprognosticnutritionalindexisapredictiveandprognosticfactorofhighgradeserousovariancancer |
_version_ |
1716801877409005568 |