Intracranial fibrosarcoma treated with adjuvant radiation and temozolomide: Report of a case and review of all published cases
Introduction: Fibrosarcoma is a rare brain tumour with 33 cases reported so far. However, there is no clear consensus about the nature of the disease and treatment as well as outcome. Methods: A MEDLINE search was carried out using MESH terms like intracranial fibrosarcoma, intraspinal fibrosarcoma,...
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doaj-971222afde1f415fbb86dd0ff8775abc2020-11-25T01:56:34ZengSpringerOpenJournal of the Egyptian National Cancer Institute1110-03622016-06-0128211111610.1016/j.jnci.2015.07.002Intracranial fibrosarcoma treated with adjuvant radiation and temozolomide: Report of a case and review of all published casesPrashanth GiridharSupriya MallickK.P. HareshSubhash GuptaP.K. JulkaG.K. RathIntroduction: Fibrosarcoma is a rare brain tumour with 33 cases reported so far. However, there is no clear consensus about the nature of the disease and treatment as well as outcome. Methods: A MEDLINE search was carried out using MESH terms like intracranial fibrosarcoma, intraspinal fibrosarcoma, fibrosarcoma meninges and fibrosarcoma brain. A total of 22 case reports and series reporting a total of 33 cases were identified. We here also report a case treated in our institute with adjuvant radiation and concurrent and maintenance temozolomide. Results: The age of presentation ranged from 2 months to 75 years (Median = 17 years). The gender ratio was found to be M:F of 1.75–1. Treatment modalities were described for 17 cases. Surgery was part of treatment in all cases while radiation was a part of treatment in 59% of cases (n = 10) and chemotherapy in 29% cases (n = 5). Survival data were available only for 8 cases and ranged from 1 day to 8 years (Median = 15.5 months). Conclusion: Fibrosarcoma is a rare disease with dismal prognosis. Surgery remains the cornerstone of therapy. Radiation confers long term disease control and survival. Chemotherapy needs to be evaluated for these tumours to improve survival.http://www.sciencedirect.com/science/article/pii/S1110036215000606FibrosarcomaIntracranialRadiotherapyChemotherapyMeninges |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Prashanth Giridhar Supriya Mallick K.P. Haresh Subhash Gupta P.K. Julka G.K. Rath |
spellingShingle |
Prashanth Giridhar Supriya Mallick K.P. Haresh Subhash Gupta P.K. Julka G.K. Rath Intracranial fibrosarcoma treated with adjuvant radiation and temozolomide: Report of a case and review of all published cases Journal of the Egyptian National Cancer Institute Fibrosarcoma Intracranial Radiotherapy Chemotherapy Meninges |
author_facet |
Prashanth Giridhar Supriya Mallick K.P. Haresh Subhash Gupta P.K. Julka G.K. Rath |
author_sort |
Prashanth Giridhar |
title |
Intracranial fibrosarcoma treated with adjuvant radiation and temozolomide: Report of a case and review of all published cases |
title_short |
Intracranial fibrosarcoma treated with adjuvant radiation and temozolomide: Report of a case and review of all published cases |
title_full |
Intracranial fibrosarcoma treated with adjuvant radiation and temozolomide: Report of a case and review of all published cases |
title_fullStr |
Intracranial fibrosarcoma treated with adjuvant radiation and temozolomide: Report of a case and review of all published cases |
title_full_unstemmed |
Intracranial fibrosarcoma treated with adjuvant radiation and temozolomide: Report of a case and review of all published cases |
title_sort |
intracranial fibrosarcoma treated with adjuvant radiation and temozolomide: report of a case and review of all published cases |
publisher |
SpringerOpen |
series |
Journal of the Egyptian National Cancer Institute |
issn |
1110-0362 |
publishDate |
2016-06-01 |
description |
Introduction: Fibrosarcoma is a rare brain tumour with 33 cases reported so far. However, there is no clear consensus about the nature of the disease and treatment as well as outcome.
Methods: A MEDLINE search was carried out using MESH terms like intracranial fibrosarcoma, intraspinal fibrosarcoma, fibrosarcoma meninges and fibrosarcoma brain. A total of 22 case reports and series reporting a total of 33 cases were identified. We here also report a case treated in our institute with adjuvant radiation and concurrent and maintenance temozolomide.
Results: The age of presentation ranged from 2 months to 75 years (Median = 17 years). The gender ratio was found to be M:F of 1.75–1. Treatment modalities were described for 17 cases. Surgery was part of treatment in all cases while radiation was a part of treatment in 59% of cases (n = 10) and chemotherapy in 29% cases (n = 5). Survival data were available only for 8 cases and ranged from 1 day to 8 years (Median = 15.5 months).
Conclusion: Fibrosarcoma is a rare disease with dismal prognosis. Surgery remains the cornerstone of therapy. Radiation confers long term disease control and survival. Chemotherapy needs to be evaluated for these tumours to improve survival. |
topic |
Fibrosarcoma Intracranial Radiotherapy Chemotherapy Meninges |
url |
http://www.sciencedirect.com/science/article/pii/S1110036215000606 |
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