Host–microbiota interactions in rheumatoid arthritis
Rheumatoid arthritis: gut and mouth microbes linked to autoimmune disease Microbes living in the gut and mouth have been implicated in the development of rheumatoid arthritis (RA) and treatments that promote the growth of healthier bacterial communities may help weaken this autoimmune disease. Yuich...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-12-01
|
Series: | Experimental and Molecular Medicine |
Online Access: | https://doi.org/10.1038/s12276-019-0283-6 |
id |
doaj-97268d76cb7d47eb97c11f5d78e0edec |
---|---|
record_format |
Article |
spelling |
doaj-97268d76cb7d47eb97c11f5d78e0edec2020-12-13T12:38:32ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132019-12-0151121610.1038/s12276-019-0283-6Host–microbiota interactions in rheumatoid arthritisYuichi Maeda0Kiyoshi Takeda1Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka UniversityLaboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, WPI Immunology Frontier Research Center, Osaka UniversityRheumatoid arthritis: gut and mouth microbes linked to autoimmune disease Microbes living in the gut and mouth have been implicated in the development of rheumatoid arthritis (RA) and treatments that promote the growth of healthier bacterial communities may help weaken this autoimmune disease. Yuichi Maeda and Kiyoshi Takeda from Osaka University, Japan, review data from mice and humans linking RA to altered microbial compositions in the gut. They focus on a particular bacterium called Prevotella copri, which is found at much higher numbers in the gastrointestinal tracts of people with newly diagnosed RA than in those without the disease. Certain mouth-dwelling bacteria may also help exacerbate RA through the induction of antibodies directed against the host. The exact molecular mechanism by which gut and oral microbes contribute to RA remains unclear.https://doi.org/10.1038/s12276-019-0283-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuichi Maeda Kiyoshi Takeda |
spellingShingle |
Yuichi Maeda Kiyoshi Takeda Host–microbiota interactions in rheumatoid arthritis Experimental and Molecular Medicine |
author_facet |
Yuichi Maeda Kiyoshi Takeda |
author_sort |
Yuichi Maeda |
title |
Host–microbiota interactions in rheumatoid arthritis |
title_short |
Host–microbiota interactions in rheumatoid arthritis |
title_full |
Host–microbiota interactions in rheumatoid arthritis |
title_fullStr |
Host–microbiota interactions in rheumatoid arthritis |
title_full_unstemmed |
Host–microbiota interactions in rheumatoid arthritis |
title_sort |
host–microbiota interactions in rheumatoid arthritis |
publisher |
Nature Publishing Group |
series |
Experimental and Molecular Medicine |
issn |
1226-3613 2092-6413 |
publishDate |
2019-12-01 |
description |
Rheumatoid arthritis: gut and mouth microbes linked to autoimmune disease Microbes living in the gut and mouth have been implicated in the development of rheumatoid arthritis (RA) and treatments that promote the growth of healthier bacterial communities may help weaken this autoimmune disease. Yuichi Maeda and Kiyoshi Takeda from Osaka University, Japan, review data from mice and humans linking RA to altered microbial compositions in the gut. They focus on a particular bacterium called Prevotella copri, which is found at much higher numbers in the gastrointestinal tracts of people with newly diagnosed RA than in those without the disease. Certain mouth-dwelling bacteria may also help exacerbate RA through the induction of antibodies directed against the host. The exact molecular mechanism by which gut and oral microbes contribute to RA remains unclear. |
url |
https://doi.org/10.1038/s12276-019-0283-6 |
work_keys_str_mv |
AT yuichimaeda hostmicrobiotainteractionsinrheumatoidarthritis AT kiyoshitakeda hostmicrobiotainteractionsinrheumatoidarthritis |
_version_ |
1724384432345841664 |