Ferulic acid prevents aflatoxin B1-induced liver injury in rats via inhibiting cytochrome P450 enzyme, activating Nrf2/GST pathway and regulating mitochondrial pathway

Ferulic acid prevents aflatoxin B1-induced liver injury in rats via inhibiting cytochrome P450 enzyme, activating Nrf2/GST pathway and regulating mitochondrial pathway

Aflatoxin B1 (AFB1) causes oxidative stress and hepatocyte apoptosis through its epoxidized metabolite AFBO, which is catalyzed by CYP450 enzymes. Ferulic acid (FA) is a phenolic acid commonly found in plants and is known for its antioxidant capacity. However, the role of FA in AFB1-induced liver in...

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Bibliographic Details
Main Authors: Xinghe Wang, Yang He, Jinlong Tian, Ishfaq Muhammad, Mingchun Liu, Changde Wu, Chang Xu, Xiaohuan Zhang
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Ferulic acid
AFB1
CYP450
Apoptosis
Oxidative stress
Hepatocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321007363

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