Prevalence of Metabolic Syndrome and Urinary Albumin to Creatinine Ratio as a Predictor of Cardiovascular Disease in Metabolic Syndrome Patients
Introduction: Metabolic Syndrome (MetS) is a condition that increases the risk of cardiac disease, diabetes, hypertension and may be associated with microalbuminuria. Aim: To investigate the prevalence of metabolic syndrome and to determine albumin to creatinine ratio as a predictor of cardiova...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2020-10-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/14155/45002_CE[Ra1]_F(SL)_PF1(AKA_KM)_PFA(AKA_KM)_GC(AsG_SL)_PN(SL).pdf |
Summary: | Introduction: Metabolic Syndrome (MetS) is a condition that
increases the risk of cardiac disease, diabetes, hypertension and
may be associated with microalbuminuria.
Aim: To investigate the prevalence of metabolic syndrome
and to determine albumin to creatinine ratio as a predictor of
cardiovascular disease in metabolic syndrome.
Materials and Methods: This was a hospital based crosssectional study conducted from February 2019 to January 2020
in the Department of Biochemistry and Outpatient Department
of Muzaffarnagar Medical College, Muzaffarnagar, Uttar Pradesh.
Out of enrolled 795 subjects, 452 were male and 343 were female.
The prevalence of metabolic syndrome was calculated on the
basis of metabolic syndrome criteria. Anthropometric parameters
like age, weight, height, blood pressure and the biochemical
parameters including fasting blood sugar, triglyceride, Lipid
Accumulation Product (LAP), urinary albumin, serum creatinine
and urinary Albumin to Creatinine Ratio were measured in study
population. SPSS version 16 was used for statistical analysis
and student independent sample t-test was used for comparing
differences amongst the variables. A p-value less than 0.05 was
considered as statistically significant.
Results: Out of 795 subjects, 152 patients (19.12%) were
hypertensive, 85 patients (10.69%) were diabetic and 29 patients
(3.65%) were hypertensive with diabetic. The prevalence of
metabolic syndrome was around 18.11% (144 subjects), out of
which 52.78% were female and 47.22% were male. Out of 144
Metabolic Syndrome subjects, 23 subjects were diabetic, 32 were
hypertensive, 14 were diabetic with hypertensive and 75were others.
The mean levels of urinary albumin creatinine ratio were increased
significantly in metabolic syndrome subjects and the increase in
urine Albumin to Creatinine Ratio (uACR) was more in metabolic
syndrome subjects having Diabetes and Hypertension both.
Conclusion: The present study concluded that the
microalbuminuria is associated with metabolic syndrome. The
microalbuminuria was found to be more significant in metabolic
syndrome subjects who were diabetic with hypertensive as
compared to diabetic or hypertensive alone. |
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ISSN: | 2249-782X 0973-709X |