Cellular and Molecular Connections between Autophagy and Inflammation
Autophagy is an intracellular catabolic pathway essential for the recycling of proteins and larger substrates such as aggregates, apoptotic corpses, or long-lived and superfluous organelles whose accumulation could be toxic for cells. Because of its unique feature to engulf part of cytoplasm in doub...
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Online Access: | http://dx.doi.org/10.1155/2015/398483 |
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doaj-97417f4b4bad434db14589d8fdca49272020-11-24T22:54:13ZengHindawi LimitedMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/398483398483Cellular and Molecular Connections between Autophagy and InflammationPierre Lapaquette0Jean Guzzo1Lionel Bretillon2Marie-Agnès Bringer3Université Bourgogne Franche-Comté, UMR PAM, Équipe Vin, Aliment, Microbiologie, Stress, 21000 Dijon, FranceUniversité Bourgogne Franche-Comté, UMR PAM, Équipe Vin, Aliment, Microbiologie, Stress, 21000 Dijon, FranceINRA, UMR1324 Centre des Sciences du Goût et de l’Alimentation, 21000 Dijon, FranceINRA, UMR1324 Centre des Sciences du Goût et de l’Alimentation, 21000 Dijon, FranceAutophagy is an intracellular catabolic pathway essential for the recycling of proteins and larger substrates such as aggregates, apoptotic corpses, or long-lived and superfluous organelles whose accumulation could be toxic for cells. Because of its unique feature to engulf part of cytoplasm in double-membrane cup-shaped structures, which further fuses with lysosomes, autophagy is also involved in the elimination of host cell invaders and takes an active part of the innate and adaptive immune response. Its pivotal role in maintenance of the inflammatory balance makes dysfunctions of the autophagy process having important pathological consequences. Indeed, defects in autophagy are associated with a wide range of human diseases including metabolic disorders (diabetes and obesity), inflammatory bowel disease (IBD), and cancer. In this review, we will focus on interrelations that exist between inflammation and autophagy. We will discuss in particular how mediators of inflammation can regulate autophagy activity and, conversely, how autophagy shapes the inflammatory response. Impact of genetic polymorphisms in autophagy-related gene on inflammatory bowel disease will be also discussed.http://dx.doi.org/10.1155/2015/398483 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pierre Lapaquette Jean Guzzo Lionel Bretillon Marie-Agnès Bringer |
spellingShingle |
Pierre Lapaquette Jean Guzzo Lionel Bretillon Marie-Agnès Bringer Cellular and Molecular Connections between Autophagy and Inflammation Mediators of Inflammation |
author_facet |
Pierre Lapaquette Jean Guzzo Lionel Bretillon Marie-Agnès Bringer |
author_sort |
Pierre Lapaquette |
title |
Cellular and Molecular Connections between Autophagy and Inflammation |
title_short |
Cellular and Molecular Connections between Autophagy and Inflammation |
title_full |
Cellular and Molecular Connections between Autophagy and Inflammation |
title_fullStr |
Cellular and Molecular Connections between Autophagy and Inflammation |
title_full_unstemmed |
Cellular and Molecular Connections between Autophagy and Inflammation |
title_sort |
cellular and molecular connections between autophagy and inflammation |
publisher |
Hindawi Limited |
series |
Mediators of Inflammation |
issn |
0962-9351 1466-1861 |
publishDate |
2015-01-01 |
description |
Autophagy is an intracellular catabolic pathway essential for the recycling of proteins and larger substrates such as aggregates, apoptotic corpses, or long-lived and superfluous organelles whose accumulation could be toxic for cells. Because of its unique feature to engulf part of cytoplasm in double-membrane cup-shaped structures, which further fuses with lysosomes, autophagy is also involved in the elimination of host cell invaders and takes an active part of the innate and adaptive immune response. Its pivotal role in maintenance of the inflammatory balance makes dysfunctions of the autophagy process having important pathological consequences. Indeed, defects in autophagy are associated with a wide range of human diseases including metabolic disorders (diabetes and obesity), inflammatory bowel disease (IBD), and cancer. In this review, we will focus on interrelations that exist between inflammation and autophagy. We will discuss in particular how mediators of inflammation can regulate autophagy activity and, conversely, how autophagy shapes the inflammatory response. Impact of genetic polymorphisms in autophagy-related gene on inflammatory bowel disease will be also discussed. |
url |
http://dx.doi.org/10.1155/2015/398483 |
work_keys_str_mv |
AT pierrelapaquette cellularandmolecularconnectionsbetweenautophagyandinflammation AT jeanguzzo cellularandmolecularconnectionsbetweenautophagyandinflammation AT lionelbretillon cellularandmolecularconnectionsbetweenautophagyandinflammation AT marieagnesbringer cellularandmolecularconnectionsbetweenautophagyandinflammation |
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1725661390798061568 |