| Summary: | MicroRNA regulation is crucial for gene expression and cell functions. It has been linked to tumorigenesis, development and metastasis in colorectal cancer (CRC). Recently, the <i>let-7</i> family has been identified as a tumor suppressor in different types of cancers. However, the function of the <i>let-7</i> family in CRC metastasis has not been fully investigated. Here, we focused on analyzing the role of <i>let-7g</i> in CRC. The Cancer Genome Atlas (TCGA) genomic datasets of CRC and detailed data from a Taiwanese CRC cohort were applied to study the expression pattern of <i>let-7g</i>. In addition, in vitro as well as in vivo studies have been performed to uncover the effects of <i>let-7g</i> on CRC. We found that the expression of <i>let-7g</i> was significantly lower in CRC specimens. Our results further supported the inhibitory effects of <i>let-7g</i> on CRC cell migration, invasion and extracellular calcium influx through store-operated calcium channels. We report a critical role for <i>let-7g</i> in the pathogenesis of CRC and suggest <i>let-7g</i> as a potential therapeutic target for CRC treatment.
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