Lignin-Derived Biomaterials for Drug Release and Tissue Engineering
Renewable resources are gaining increasing interest as a source for environmentally benign biomaterials, such as drug encapsulation/release compounds, and scaffolds for tissue engineering in regenerative medicine. Being the second largest naturally abundant polymer, the interest in lignin valorizati...
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doaj-9778b91ff57745599a540b796489a1e92020-11-25T01:08:07ZengMDPI AGMolecules1420-30492018-07-01238188510.3390/molecules23081885molecules23081885Lignin-Derived Biomaterials for Drug Release and Tissue EngineeringMarkus Witzler0Abla Alzagameem1Michel Bergs2Basma El Khaldi-Hansen3Stephanie E. Klein4Dorothee Hielscher5Birgit Kamm6Judith Kreyenschmidt7Edda Tobiasch8Margit Schulze9Department of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, von-Liebig-Str. 20, D-53359 Rheinbach, GermanyDepartment of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, von-Liebig-Str. 20, D-53359 Rheinbach, GermanyDepartment of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, von-Liebig-Str. 20, D-53359 Rheinbach, GermanyDepartment of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, von-Liebig-Str. 20, D-53359 Rheinbach, GermanyDepartment of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, von-Liebig-Str. 20, D-53359 Rheinbach, GermanyDepartment of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, von-Liebig-Str. 20, D-53359 Rheinbach, GermanyFaculty of Environment and Natural Sciences, Brandenburg University of Technology BTU Cottbus-Senftenberg, Platz der Deutschen Einheit 1, D-03046 Cottbus, GermanyRheinische Friedrich Wilhelms-University Bonn, Katzenburgweg 7-9, D-53115 Bonn, GermanyDepartment of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, von-Liebig-Str. 20, D-53359 Rheinbach, GermanyDepartment of Natural Sciences, Bonn-Rhein-Sieg University of Applied Sciences, von-Liebig-Str. 20, D-53359 Rheinbach, GermanyRenewable resources are gaining increasing interest as a source for environmentally benign biomaterials, such as drug encapsulation/release compounds, and scaffolds for tissue engineering in regenerative medicine. Being the second largest naturally abundant polymer, the interest in lignin valorization for biomedical utilization is rapidly growing. Depending on its resource and isolation procedure, lignin shows specific antioxidant and antimicrobial activity. Today, efforts in research and industry are directed toward lignin utilization as a renewable macromolecular building block for the preparation of polymeric drug encapsulation and scaffold materials. Within the last five years, remarkable progress has been made in isolation, functionalization and modification of lignin and lignin-derived compounds. However, the literature so far mainly focuses lignin-derived fuels, lubricants and resins. The purpose of this review is to summarize the current state of the art and to highlight the most important results in the field of lignin-based materials for potential use in biomedicine (reported in 2014–2018). Special focus is placed on lignin-derived nanomaterials for drug encapsulation and release as well as lignin hybrid materials used as scaffolds for guided bone regeneration in stem cell-based therapies.http://www.mdpi.com/1420-3049/23/8/1885biomaterialbone regenerationdrug releasehydrogelligninmultivariate data processingosteogenesisscaffoldsstem cellstissue engineering |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Markus Witzler Abla Alzagameem Michel Bergs Basma El Khaldi-Hansen Stephanie E. Klein Dorothee Hielscher Birgit Kamm Judith Kreyenschmidt Edda Tobiasch Margit Schulze |
spellingShingle |
Markus Witzler Abla Alzagameem Michel Bergs Basma El Khaldi-Hansen Stephanie E. Klein Dorothee Hielscher Birgit Kamm Judith Kreyenschmidt Edda Tobiasch Margit Schulze Lignin-Derived Biomaterials for Drug Release and Tissue Engineering Molecules biomaterial bone regeneration drug release hydrogel lignin multivariate data processing osteogenesis scaffolds stem cells tissue engineering |
author_facet |
Markus Witzler Abla Alzagameem Michel Bergs Basma El Khaldi-Hansen Stephanie E. Klein Dorothee Hielscher Birgit Kamm Judith Kreyenschmidt Edda Tobiasch Margit Schulze |
author_sort |
Markus Witzler |
title |
Lignin-Derived Biomaterials for Drug Release and Tissue Engineering |
title_short |
Lignin-Derived Biomaterials for Drug Release and Tissue Engineering |
title_full |
Lignin-Derived Biomaterials for Drug Release and Tissue Engineering |
title_fullStr |
Lignin-Derived Biomaterials for Drug Release and Tissue Engineering |
title_full_unstemmed |
Lignin-Derived Biomaterials for Drug Release and Tissue Engineering |
title_sort |
lignin-derived biomaterials for drug release and tissue engineering |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2018-07-01 |
description |
Renewable resources are gaining increasing interest as a source for environmentally benign biomaterials, such as drug encapsulation/release compounds, and scaffolds for tissue engineering in regenerative medicine. Being the second largest naturally abundant polymer, the interest in lignin valorization for biomedical utilization is rapidly growing. Depending on its resource and isolation procedure, lignin shows specific antioxidant and antimicrobial activity. Today, efforts in research and industry are directed toward lignin utilization as a renewable macromolecular building block for the preparation of polymeric drug encapsulation and scaffold materials. Within the last five years, remarkable progress has been made in isolation, functionalization and modification of lignin and lignin-derived compounds. However, the literature so far mainly focuses lignin-derived fuels, lubricants and resins. The purpose of this review is to summarize the current state of the art and to highlight the most important results in the field of lignin-based materials for potential use in biomedicine (reported in 2014–2018). Special focus is placed on lignin-derived nanomaterials for drug encapsulation and release as well as lignin hybrid materials used as scaffolds for guided bone regeneration in stem cell-based therapies. |
topic |
biomaterial bone regeneration drug release hydrogel lignin multivariate data processing osteogenesis scaffolds stem cells tissue engineering |
url |
http://www.mdpi.com/1420-3049/23/8/1885 |
work_keys_str_mv |
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