Induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury
The greatest challenge to successful treatment of spinal cord injury is the limited regenerative capacity of the central nervous system and its inability to replace lost neurons and severed axons following injury. Neural stem cell grafts derived from fetal central nervous system tissue or embryonic...
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Wolters Kluwer Medknow Publications
2015-01-01
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doaj-97833657dc0649f7869c601e7b9e93c42020-11-25T03:43:14ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53741876-79582015-01-01101101610.4103/1673-5374.150638Induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury Corinne A Lee-KubliPaul LuThe greatest challenge to successful treatment of spinal cord injury is the limited regenerative capacity of the central nervous system and its inability to replace lost neurons and severed axons following injury. Neural stem cell grafts derived from fetal central nervous system tissue or embryonic stem cells have shown therapeutic promise by differentiation into neurons and glia that have the potential to form functional neuronal relays across injured spinal cord segments. However, implementation of fetal-derived or embryonic stem cell-derived neural stem cell therapies for patients with spinal cord injury raises ethical concerns. Induced pluripotent stem cells can be generated from adult somatic cells and differentiated into neural stem cells suitable for therapeutic use, thereby providing an ethical source of implantable cells that can be made in an autologous fashion to avoid problems of immune rejection. This review discusses the therapeutic potential of human induced pluripotent stem cell-derived neural stem cell transplantation for treatment of spinal cord injury, as well as addressing potential mechanisms, future perspectives and challenges.http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=1;spage=10;epage=16;aulast=Lee-Kublitransplantation; axonal growth; axonal regeneration; neuroprotection; remyelination; differentiation; neuronal relay; human; astrocytes; neurons; oligodendrocytes; secondary degeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Corinne A Lee-Kubli Paul Lu |
spellingShingle |
Corinne A Lee-Kubli Paul Lu Induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury Neural Regeneration Research transplantation; axonal growth; axonal regeneration; neuroprotection; remyelination; differentiation; neuronal relay; human; astrocytes; neurons; oligodendrocytes; secondary degeneration |
author_facet |
Corinne A Lee-Kubli Paul Lu |
author_sort |
Corinne A Lee-Kubli |
title |
Induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury |
title_short |
Induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury |
title_full |
Induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury |
title_fullStr |
Induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury |
title_full_unstemmed |
Induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury |
title_sort |
induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury |
publisher |
Wolters Kluwer Medknow Publications |
series |
Neural Regeneration Research |
issn |
1673-5374 1876-7958 |
publishDate |
2015-01-01 |
description |
The greatest challenge to successful treatment of spinal cord injury is the limited regenerative capacity of the central nervous system and its inability to replace lost neurons and severed axons following injury. Neural stem cell grafts derived from fetal central nervous system tissue or embryonic stem cells have shown therapeutic promise by differentiation into neurons and glia that have the potential to form functional neuronal relays across injured spinal cord segments. However, implementation of fetal-derived or embryonic stem cell-derived neural stem cell therapies for patients with spinal cord injury raises ethical concerns. Induced pluripotent stem cells can be generated from adult somatic cells and differentiated into neural stem cells suitable for therapeutic use, thereby providing an ethical source of implantable cells that can be made in an autologous fashion to avoid problems of immune rejection. This review discusses the therapeutic potential of human induced pluripotent stem cell-derived neural stem cell transplantation for treatment of spinal cord injury, as well as addressing potential mechanisms, future perspectives and challenges. |
topic |
transplantation; axonal growth; axonal regeneration; neuroprotection; remyelination; differentiation; neuronal relay; human; astrocytes; neurons; oligodendrocytes; secondary degeneration |
url |
http://www.nrronline.org/article.asp?issn=1673-5374;year=2015;volume=10;issue=1;spage=10;epage=16;aulast=Lee-Kubli |
work_keys_str_mv |
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