EFFECT OF PROGRESSIVE ABSENCE EPILEPSY AND ITS TREATMENT ON HEMODYNAMICS AND AUTONOMIC REGULATION OF THE HEART RHYTHM

• Main Authors: M.L. Mamalyga, L.M. Mamalyga
• Format: Article
• Language: English
• Published: Amaltea Medical Publishing House 2019-03-01
• Series: Romanian Journal of Neurology
• Subjects: absence epilepsy; anticonvulsant therapy; hemodynamics; heart rate variability
• Online Access: https://revistemedicale.amaltea.ro/Romanian_Journal_of_NEUROLOGY/Revista_Romana_de_NEUROLOGIE-2019-Nr.1/RJN_2019_1_Art-04.pdf

Objective. To study hemodynamics and autonomic regulation of heart rhythm in patients with progressive non-convulsive convulsive activity of the brain and its treatment in WAG/Rij rats with genetically determined absence epilepsy. Methods. Studies were conducted on rats of different age groups of the WAG/Rij and Wistar lines. The following methods were used for the study: telemetric monitoring of EEG, ECG, aortic blood pressure, echocardiography. Results. Progressive convulsive activity (CA) in WAG/Rij rats with absence epilepsy (AE) is accompanied by a violation of the autonomic regulation of the heart and an increase in repolarization intervals of the left ventricle. In 6- and 9-month-old animals, anticonvulsant therapy with Convulex contributes to the improvement of the vegetative regulation of the heart. However, in 12-month-old animals, a decrease in peak-wave activity by the Convulex does not improve the impaired cardiac regulation and does not reduce the high risk of the occurrence of life-threatening arrhythmias. Conclusions. The decrease in convulsive activity with Convulex makes it possible to improve the autonomic regulation of the heart. However, this possibility persists as long as progressive AE does not exceed a certain threshold. Thereafter, a decrease in brain SWD activity with Convulex does not improve impaired cardiac regulation.