Lecithin- cholesterol acyltransferase and relationship with Platelet-activating factor in AB blood phenotype

• Main Authors: Suayip Birinci, Belkis Koctekin, Necat Yilmaz
• Format: Article
• Language: English
• Published: DiscoverSys 2020-04-01
• Series: Bali Medical Journal
• Subjects: abo blood system, ab phenotype, atherosclerosis, atherogenic index of plasma, lecithin-cholesterol acyltransferase, platelet-activating factor, triglycerides, high-density lipoprotein cholesterol
• Online Access: https://balimedicaljournal.org/index.php/bmj/article/view/1746
• ISSN: 2089-1180; 2302-2914

<p><strong>Objectives:</strong> This study aimed to determine the association between Lecithin-cholesterol acyltransferase (LCAT) and Platelet-activating factor (PAF) with atherogenic potential in the ABO blood system.</p><p><strong>Background</strong>: The current study is the first study that focuses on healthy blood donors and investigating a relationship between ABO blood groups and LCAT enzyme and PAF, which plays a notable role in atherogenesis.</p><p><strong>Methods:</strong> ABO blood types characterize the role of the individualistic phenotype. Hence, it is generally assumed that ABO blood phenotypes are involved with many diseases. This cross-sectional study involved 176 healthy subjects with different ABO blood phenotypes.<strong> </strong>Measurements of routine lipids, LCAT, PAF and atherogenic plasma index (AIP) were performed in these subjects.</p><p><strong>Results:</strong> Our most important finding was that individuals with blood group AB have statistically significant lower LCAT levels in serum. Additionally, there was a moderately negative correlation between LCAT and triglycerides in the AB blood phenotype (r=-0.452, P=0.02). Nevertheless, there were statistically significant correlations between LCAT levels and PAF levels of subjects with only non –O blood phenotypes (A, B and AB). Serum AIP values were statistically significantly higher in the AB blood group.</p><p><strong>Conclusion:</strong> The present study suggests that blood group AB can be associated with decreased LCAT   levels when compared to the non- AB phenotypes. We suggest that LACT and AIP may be helpful biomarkers to illustrate atherogenic risk in AB blood phenotype, although this requires further investigation.</p>