Where Do They Come from and Where Do They Go: Candidates for Regulating Extracellular Vesicle Formation in Fungi

In the past few years, extracellular vesicles (EVs) from at least eight fungal species were characterized. EV proteome in four fungal species indicated putative biogenesis pathways and suggested interesting similarities with mammalian exosomes. Moreover, as observed for mammalian exosomes, fungal EV...

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Main Authors:	Marcio L. Rodrigues, Rodrigo M. C. Godinho, Luna S. Joffe, Débora L. Oliveira, Juliana Rizzo
Format:	Article
Language:	English
Published:	MDPI AG 2013-05-01
Series:	International Journal of Molecular Sciences
Subjects:	fungal extracellular vesicles extracellular vesicle biogenesis exosomes flippases GRASP
Online Access:	http://www.mdpi.com/1422-0067/14/5/9581

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spelling	doaj-978abd49e94747d196a167540b7538892020-11-25T00:06:17ZengMDPI AGInternational Journal of Molecular Sciences1422-00672013-05-011459581960310.3390/ijms14059581Where Do They Come from and Where Do They Go: Candidates for Regulating Extracellular Vesicle Formation in FungiMarcio L. RodriguesRodrigo M. C. GodinhoLuna S. JoffeDébora L. OliveiraJuliana RizzoIn the past few years, extracellular vesicles (EVs) from at least eight fungal species were characterized. EV proteome in four fungal species indicated putative biogenesis pathways and suggested interesting similarities with mammalian exosomes. Moreover, as observed for mammalian exosomes, fungal EVs were demonstrated to be immunologically active. Here we review the seminal and most recent findings related to the production of EVs by fungi. Based on the current literature about secretion of fungal molecules and biogenesis of EVs in eukaryotes, we focus our discussion on a list of cellular proteins with the potential to regulate vesicle biogenesis in the fungi.http://www.mdpi.com/1422-0067/14/5/9581fungal extracellular vesiclesextracellular vesicle biogenesisexosomesflippasesGRASP
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Marcio L. Rodrigues Rodrigo M. C. Godinho Luna S. Joffe Débora L. Oliveira Juliana Rizzo
spellingShingle	Marcio L. Rodrigues Rodrigo M. C. Godinho Luna S. Joffe Débora L. Oliveira Juliana Rizzo Where Do They Come from and Where Do They Go: Candidates for Regulating Extracellular Vesicle Formation in Fungi International Journal of Molecular Sciences fungal extracellular vesicles extracellular vesicle biogenesis exosomes flippases GRASP
author_facet	Marcio L. Rodrigues Rodrigo M. C. Godinho Luna S. Joffe Débora L. Oliveira Juliana Rizzo
author_sort	Marcio L. Rodrigues
title	Where Do They Come from and Where Do They Go: Candidates for Regulating Extracellular Vesicle Formation in Fungi
title_short	Where Do They Come from and Where Do They Go: Candidates for Regulating Extracellular Vesicle Formation in Fungi
title_full	Where Do They Come from and Where Do They Go: Candidates for Regulating Extracellular Vesicle Formation in Fungi
title_fullStr	Where Do They Come from and Where Do They Go: Candidates for Regulating Extracellular Vesicle Formation in Fungi
title_full_unstemmed	Where Do They Come from and Where Do They Go: Candidates for Regulating Extracellular Vesicle Formation in Fungi
title_sort	where do they come from and where do they go: candidates for regulating extracellular vesicle formation in fungi
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2013-05-01
description	In the past few years, extracellular vesicles (EVs) from at least eight fungal species were characterized. EV proteome in four fungal species indicated putative biogenesis pathways and suggested interesting similarities with mammalian exosomes. Moreover, as observed for mammalian exosomes, fungal EVs were demonstrated to be immunologically active. Here we review the seminal and most recent findings related to the production of EVs by fungi. Based on the current literature about secretion of fungal molecules and biogenesis of EVs in eukaryotes, we focus our discussion on a list of cellular proteins with the potential to regulate vesicle biogenesis in the fungi.
topic	fungal extracellular vesicles extracellular vesicle biogenesis exosomes flippases GRASP
url	http://www.mdpi.com/1422-0067/14/5/9581
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Where Do They Come from and Where Do They Go: Candidates for Regulating Extracellular Vesicle Formation in Fungi

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