Dementia risk in women higher in same‐sex than opposite‐sex twins
Abstract Introduction Hormones may be one possible mechanism underlying sex differences in dementia incidence. We examined whether presumed differential prenatal hormone milieu is related to dementia risk by comparing dementia rates in same‐ and opposite‐sex dizygotic twin pairs in male and female t...
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Online Access: | https://doi.org/10.1002/dad2.12049 |
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doaj-9794bd0763b64fb0894fec2f00a43d7d2021-04-15T14:35:47ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292020-01-01121n/an/a10.1002/dad2.12049Dementia risk in women higher in same‐sex than opposite‐sex twinsJing Luo0Christopher R. Beam1Ida K. Karlsson2Christian J. Pike3Chandra A. Reynolds4Margaret Gatz5Department of Psychology University of Southern California Los Angeles California USADepartment of Psychology University of Southern California Los Angeles California USAInstitute of Gerontology and Aging Research Network – Jönköping (ARN‐J) School of Health and Welfare, Jönköping University Jönköping SwedenLeonard Davis School of Gerontology University of Southern California Los Angeles California USADepartment of Psychology University of California, Riverside Riverside California USADepartment of Psychology University of Southern California Los Angeles California USAAbstract Introduction Hormones may be one possible mechanism underlying sex differences in dementia incidence. We examined whether presumed differential prenatal hormone milieu is related to dementia risk by comparing dementia rates in same‐ and opposite‐sex dizygotic twin pairs in male and female twins. Methods The sample comprised 43,254 individuals from dizygotic twin pairs aged 60 and older from the Swedish Twin Registry. Survival analyses were conducted separately for females and males. Results Female twins from opposite‐sex pairs had significantly lower dementia risk than female twins from same‐sex pairs, but the differences emerged only after age 70 (hazard ratio = 0.64, P = 0.004). Results were not explained by postnatal risk factors for dementia, and no interaction between twin type and apolipoprotein E (APOE) ε4 was found. Male twins from same‐sex versus opposite‐sex pairs did not differ significantly. Discussion The results suggest that relatively masculine prenatal hormone milieus correlate with lower dementia risk in females.https://doi.org/10.1002/dad2.12049apolipoprotein E4dementiasex differencestestosteronetwin study |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jing Luo Christopher R. Beam Ida K. Karlsson Christian J. Pike Chandra A. Reynolds Margaret Gatz |
spellingShingle |
Jing Luo Christopher R. Beam Ida K. Karlsson Christian J. Pike Chandra A. Reynolds Margaret Gatz Dementia risk in women higher in same‐sex than opposite‐sex twins Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring apolipoprotein E4 dementia sex differences testosterone twin study |
author_facet |
Jing Luo Christopher R. Beam Ida K. Karlsson Christian J. Pike Chandra A. Reynolds Margaret Gatz |
author_sort |
Jing Luo |
title |
Dementia risk in women higher in same‐sex than opposite‐sex twins |
title_short |
Dementia risk in women higher in same‐sex than opposite‐sex twins |
title_full |
Dementia risk in women higher in same‐sex than opposite‐sex twins |
title_fullStr |
Dementia risk in women higher in same‐sex than opposite‐sex twins |
title_full_unstemmed |
Dementia risk in women higher in same‐sex than opposite‐sex twins |
title_sort |
dementia risk in women higher in same‐sex than opposite‐sex twins |
publisher |
Wiley |
series |
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
issn |
2352-8729 |
publishDate |
2020-01-01 |
description |
Abstract Introduction Hormones may be one possible mechanism underlying sex differences in dementia incidence. We examined whether presumed differential prenatal hormone milieu is related to dementia risk by comparing dementia rates in same‐ and opposite‐sex dizygotic twin pairs in male and female twins. Methods The sample comprised 43,254 individuals from dizygotic twin pairs aged 60 and older from the Swedish Twin Registry. Survival analyses were conducted separately for females and males. Results Female twins from opposite‐sex pairs had significantly lower dementia risk than female twins from same‐sex pairs, but the differences emerged only after age 70 (hazard ratio = 0.64, P = 0.004). Results were not explained by postnatal risk factors for dementia, and no interaction between twin type and apolipoprotein E (APOE) ε4 was found. Male twins from same‐sex versus opposite‐sex pairs did not differ significantly. Discussion The results suggest that relatively masculine prenatal hormone milieus correlate with lower dementia risk in females. |
topic |
apolipoprotein E4 dementia sex differences testosterone twin study |
url |
https://doi.org/10.1002/dad2.12049 |
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