Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion.

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion.

Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites are essential for successful host infection....

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Main Authors: Stanislas Tomavo, Christian Slomianny, Markus Meissner, Vern B Carruthers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3812028?pdf=render
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spelling doaj-9798a92e0e68431caf21ae3d8a3a0da02020-11-25T00:57:37ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742013-10-01910e100362910.1371/journal.ppat.1003629Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion.Stanislas TomavoChristian SlomiannyMarkus MeissnerVern B CarruthersToxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites are essential for successful host infection. New findings reveal that the contents of these organelles, which are transported through the endoplasmic reticulum (ER) and Golgi, also require the parasite endosome-like system to access their respective organelles. In this review, we discuss recent findings that demonstrate that these parasites reduced their endosomal system and modified classical regulators of this pathway for the biogenesis of apical organelles.http://europepmc.org/articles/PMC3812028?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Stanislas Tomavo
Christian Slomianny
Markus Meissner
Vern B Carruthers
spellingShingle Stanislas Tomavo
Christian Slomianny
Markus Meissner
Vern B Carruthers
Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion.
PLoS Pathogens
author_facet Stanislas Tomavo
Christian Slomianny
Markus Meissner
Vern B Carruthers
author_sort Stanislas Tomavo
title Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion.
title_short Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion.
title_full Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion.
title_fullStr Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion.
title_full_unstemmed Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion.
title_sort protein trafficking through the endosomal system prepares intracellular parasites for a home invasion.
publisher Public Library of Science (PLoS)
series PLoS Pathogens
issn 1553-7366
1553-7374
publishDate 2013-10-01
description Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites are essential for successful host infection. New findings reveal that the contents of these organelles, which are transported through the endoplasmic reticulum (ER) and Golgi, also require the parasite endosome-like system to access their respective organelles. In this review, we discuss recent findings that demonstrate that these parasites reduced their endosomal system and modified classical regulators of this pathway for the biogenesis of apical organelles.
url http://europepmc.org/articles/PMC3812028?pdf=render
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AT christianslomianny proteintraffickingthroughtheendosomalsystempreparesintracellularparasitesforahomeinvasion
AT markusmeissner proteintraffickingthroughtheendosomalsystempreparesintracellularparasitesforahomeinvasion
AT vernbcarruthers proteintraffickingthroughtheendosomalsystempreparesintracellularparasitesforahomeinvasion
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