Co-exposure to metals and polycyclic aromatic hydrocarbons, microRNA expression, and early health damage in coke oven workers
Background: All humans are now co-exposed to multiple toxic chemicals, among which metals and polycyclic aromatic hydrocarbons (PAHs) are of special concern as they are often present at high levels in various human environments. They can also induce similar early health damage, such as genetic damag...
Main Authors: | , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2019-01-01
|
Series: | Environment International |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412018317021 |
id |
doaj-979bdf9881724e4e8fc5b91954205246 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qifei Deng Xiayun Dai Wei Feng Suli Huang Yu Yuan Yongmei Xiao Zhaorui Zhang Na Deng Huaxin Deng Xiao Zhang Dan Kuang Xiaohai Li Wangzhen Zhang Xiaomin Zhang Huan Guo Tangchun Wu |
spellingShingle |
Qifei Deng Xiayun Dai Wei Feng Suli Huang Yu Yuan Yongmei Xiao Zhaorui Zhang Na Deng Huaxin Deng Xiao Zhang Dan Kuang Xiaohai Li Wangzhen Zhang Xiaomin Zhang Huan Guo Tangchun Wu Co-exposure to metals and polycyclic aromatic hydrocarbons, microRNA expression, and early health damage in coke oven workers Environment International |
author_facet |
Qifei Deng Xiayun Dai Wei Feng Suli Huang Yu Yuan Yongmei Xiao Zhaorui Zhang Na Deng Huaxin Deng Xiao Zhang Dan Kuang Xiaohai Li Wangzhen Zhang Xiaomin Zhang Huan Guo Tangchun Wu |
author_sort |
Qifei Deng |
title |
Co-exposure to metals and polycyclic aromatic hydrocarbons, microRNA expression, and early health damage in coke oven workers |
title_short |
Co-exposure to metals and polycyclic aromatic hydrocarbons, microRNA expression, and early health damage in coke oven workers |
title_full |
Co-exposure to metals and polycyclic aromatic hydrocarbons, microRNA expression, and early health damage in coke oven workers |
title_fullStr |
Co-exposure to metals and polycyclic aromatic hydrocarbons, microRNA expression, and early health damage in coke oven workers |
title_full_unstemmed |
Co-exposure to metals and polycyclic aromatic hydrocarbons, microRNA expression, and early health damage in coke oven workers |
title_sort |
co-exposure to metals and polycyclic aromatic hydrocarbons, microrna expression, and early health damage in coke oven workers |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2019-01-01 |
description |
Background: All humans are now co-exposed to multiple toxic chemicals, among which metals and polycyclic aromatic hydrocarbons (PAHs) are of special concern as they are often present at high levels in various human environments. They can also induce similar early health damage, such as genetic damage, oxidative stress, and heart rate variability (HRV). Exposure to metals, PAHs, and their combined pollutants can alter microRNA (miRNA) expression patterns. Objectives: To explore the associations of metal-PAH co-exposure with miRNA expression, and of the associated miRNAs with early health damage. Methods: We enrolled 360 healthy male coke oven workers and quantified their exposure levels of metals and PAHs by urinary metals, urinary monohydroxy-PAHs (OH-PAHs), and plasma benzo[a]pyrene-r-7,t-8,t-9,c-10-tetrahydotetrol-albumin (BPDE-Alb) adducts, respectively. We selected and measured ten miRNAs: let-7b-5p, miR-126-3p, miR-142-5p, miR-150-5p, miR-16-5p, miR-24-3p, miR-27a-3p, miR-28-5p, miR-320b, and miR-451a. For miRNAs influenced by the effect modification of metals or PAHs and/or metal-PAH interactions, we further evaluated their associations with biomarkers for genetic damage, oxidative stress, and HRV. Results: After adjusting for PAHs and other metals, miRNA expression was found to be negatively associated with aluminum, antimony, lead, and titanium, and positively associated with molybdenum and tin (p < 0.05). Antimony showed modifying effects on the PAH-miRNA associations, while OH-PAHs and BPDE-Alb adducts modified the associations of metals with miRNAs (p for modifying effect < 0.05). Furthermore, miRNA expression was influenced by the antagonistic interactions between antimony and OH-PAHs, and by the synergistical interactions between metals and BPDE-Alb adducts (pinteraction < 0.05). Let-7b-5p, miR-126-3p, miR-16-5p, and miR-320b were additionally found to be associated with increased genetic damage in the present study [false discovery rate (FDR)-adjusted p < 0.05]. Conclusions: Associations of metal-PAH co-exposure with miRNA expression, and of associated miRNAs with early health damage, suggested potential mechanistic connections between the complex metal-PAH interactions and their deleterious effects that are worthy of further investigation. Keywords: Metals, Polycyclic aromatic hydrocarbons, Co-exposure, microRNAs, Early health damage |
url |
http://www.sciencedirect.com/science/article/pii/S0160412018317021 |
work_keys_str_mv |
AT qifeideng coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers AT xiayundai coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers AT weifeng coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers AT sulihuang coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers AT yuyuan coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers AT yongmeixiao coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers AT zhaoruizhang coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers AT nadeng coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers AT huaxindeng coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers AT xiaozhang coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers AT dankuang coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers AT xiaohaili coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers AT wangzhenzhang coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers AT xiaominzhang coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers AT huanguo coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers AT tangchunwu coexposuretometalsandpolycyclicaromatichydrocarbonsmicrornaexpressionandearlyhealthdamageincokeovenworkers |
_version_ |
1725851046924779520 |
spelling |
doaj-979bdf9881724e4e8fc5b919542052462020-11-24T21:58:38ZengElsevierEnvironment International0160-41202019-01-01122369380Co-exposure to metals and polycyclic aromatic hydrocarbons, microRNA expression, and early health damage in coke oven workersQifei Deng0Xiayun Dai1Wei Feng2Suli Huang3Yu Yuan4Yongmei Xiao5Zhaorui Zhang6Na Deng7Huaxin Deng8Xiao Zhang9Dan Kuang10Xiaohai Li11Wangzhen Zhang12Xiaomin Zhang13Huan Guo14Tangchun Wu15Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Faculty of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China; Correspondence to: Q. Deng, School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Rd, Guangzhou, 510080, Guangdong, China.State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Wuhan Prevention and Treatment Center for Occupational Diseases, Wuhan, Hubei, ChinaState Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaState Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaState Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Faculty of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Faculty of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, ChinaGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Faculty of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, ChinaState Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaState Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaState Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaState Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaInstitute of Industrial Health, Wuhan Iron and Steel Corporation, Wuhan, Hubei, ChinaState Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaState Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaState Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Correspondence to: T. Wu, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hongkong Rd, Wuhan, 430030, Hubei, China.Background: All humans are now co-exposed to multiple toxic chemicals, among which metals and polycyclic aromatic hydrocarbons (PAHs) are of special concern as they are often present at high levels in various human environments. They can also induce similar early health damage, such as genetic damage, oxidative stress, and heart rate variability (HRV). Exposure to metals, PAHs, and their combined pollutants can alter microRNA (miRNA) expression patterns. Objectives: To explore the associations of metal-PAH co-exposure with miRNA expression, and of the associated miRNAs with early health damage. Methods: We enrolled 360 healthy male coke oven workers and quantified their exposure levels of metals and PAHs by urinary metals, urinary monohydroxy-PAHs (OH-PAHs), and plasma benzo[a]pyrene-r-7,t-8,t-9,c-10-tetrahydotetrol-albumin (BPDE-Alb) adducts, respectively. We selected and measured ten miRNAs: let-7b-5p, miR-126-3p, miR-142-5p, miR-150-5p, miR-16-5p, miR-24-3p, miR-27a-3p, miR-28-5p, miR-320b, and miR-451a. For miRNAs influenced by the effect modification of metals or PAHs and/or metal-PAH interactions, we further evaluated their associations with biomarkers for genetic damage, oxidative stress, and HRV. Results: After adjusting for PAHs and other metals, miRNA expression was found to be negatively associated with aluminum, antimony, lead, and titanium, and positively associated with molybdenum and tin (p < 0.05). Antimony showed modifying effects on the PAH-miRNA associations, while OH-PAHs and BPDE-Alb adducts modified the associations of metals with miRNAs (p for modifying effect < 0.05). Furthermore, miRNA expression was influenced by the antagonistic interactions between antimony and OH-PAHs, and by the synergistical interactions between metals and BPDE-Alb adducts (pinteraction < 0.05). Let-7b-5p, miR-126-3p, miR-16-5p, and miR-320b were additionally found to be associated with increased genetic damage in the present study [false discovery rate (FDR)-adjusted p < 0.05]. Conclusions: Associations of metal-PAH co-exposure with miRNA expression, and of associated miRNAs with early health damage, suggested potential mechanistic connections between the complex metal-PAH interactions and their deleterious effects that are worthy of further investigation. Keywords: Metals, Polycyclic aromatic hydrocarbons, Co-exposure, microRNAs, Early health damagehttp://www.sciencedirect.com/science/article/pii/S0160412018317021 |