Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency
Abstract Inborn errors of metabolism are often associated with neurodevelopmental disorders and brain injury. A deficiency of aminopeptidase P1, a proline-specific endopeptidase encoded by the Xpnpep1 gene, causes neurological complications in both humans and mice. In addition, aminopeptidase P1-def...
Main Authors: | Sang Ho Yoon, Young-Soo Bae, Sung Pyo Oh, Woo Seok Song, Hanna Chang, Myoung-Hwan Kim |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-01-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-79656-6 |
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