Altered hippocampal gene expression, glial cell population, and neuronal excitability in aminopeptidase P1 deficiency

Abstract Inborn errors of metabolism are often associated with neurodevelopmental disorders and brain injury. A deficiency of aminopeptidase P1, a proline-specific endopeptidase encoded by the Xpnpep1 gene, causes neurological complications in both humans and mice. In addition, aminopeptidase P1-def...

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Bibliographic Details
Main Authors: Sang Ho Yoon, Young-Soo Bae, Sung Pyo Oh, Woo Seok Song, Hanna Chang, Myoung-Hwan Kim
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79656-6

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