MicroRNA let-7b downregulates AML1-ETO oncogene expression in t(8;21) AML by targeting its 3′UTR

MicroRNA let-7b downregulates AML1-ETO oncogene expression in t(8;21) AML by targeting its 3′UTR

Abstract Background Acute myeloid leukemia (AML) with the t(8;21)(q22;q22) chromosomal translocation is among the most common subtypes of AML and produces the AML1-ETO (RUNX1-ETO, RUNX1-RUNX1T1) oncogenic fusion gene. AML1-ETO functions as an aberrant transcription factor which plays a key role in b...

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Bibliographic Details
Main Authors: Daniel T. Johnson, Amanda G. Davis, Jie-Hua Zhou, Edward D. Ball, Dong-Er Zhang
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Experimental Hematology & Oncology
Subjects:
AML1-ETO (RUNX1-RUNX1T1)
let-7
miRNA
t(8;21) acute myeloid leukemia
Online Access:https://doi.org/10.1186/s40164-021-00204-7

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