The comparison of dyslipidemia and serum uric acid in patients with gout and asymptomatic hyperuricemia: a cross-sectional study
Abstract Background Dyslipidemia often concurs with hyperuricemia. Our study was to discover different lipid levels of gout and asymptomatic hyperuricemia and the predictors of sUA (serum uric acid) levels. Methods A cross-sectional study was performed to collect demographic, clinical variables, com...
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doaj-97ac921847504f1a812143f9c22959ba2020-11-25T02:20:09ZengBMCLipids in Health and Disease1476-511X2020-03-011911710.1186/s12944-020-1197-yThe comparison of dyslipidemia and serum uric acid in patients with gout and asymptomatic hyperuricemia: a cross-sectional studyJing Liang0Yutong Jiang1Yefei Huang2Wei Song3Xiaomin Li4Yulan Huang5Jiayong Ou6Qiujing Wei7Jieruo Gu8Department of Rheumatolgy and Immunology, Huadu Affiliated Hospital of Southern Medical UniversityDepartment of Rheumatology and Immunology, Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Rheumatology and Immunology, Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Rheumatolgy and Immunology, Huadu Affiliated Hospital of Southern Medical UniversityDepartment of Rheumatology and Immunology, Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Rheumatolgy and Immunology, Huadu Affiliated Hospital of Southern Medical UniversityDepartment of Rheumatology and Immunology, Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Rheumatology and Immunology, Third Affiliated Hospital of Sun Yat-sen UniversityDepartment of Rheumatology and Immunology, Third Affiliated Hospital of Sun Yat-sen UniversityAbstract Background Dyslipidemia often concurs with hyperuricemia. Our study was to discover different lipid levels of gout and asymptomatic hyperuricemia and the predictors of sUA (serum uric acid) levels. Methods A cross-sectional study was performed to collect demographic, clinical variables, comorbidities and laboratory testing in patients with gout and asymptomatic hyperuricemia. Group comparison was performed with Student’s t-test or Mann Whitney U test for continuous variables and chi-squared tests for categorical variables (Fisher’s exact test where appropriate) and to screen potential risk factors. Correlation of sUA levels with demographic and biochemical variables were performed by using correlation analysis. The variable with s p-value less than 0.20 during the group comparison or clinical relevance was introduced into the stepwise multiple regression model. Results Six hundred fifty-three patients with gout and 63 patients with asymptomatic hyperuricemia (> 420 μmol/L in male and > 360 μmol/L in female) were enrolled, including 553 (84.7%) males. The mean age was 47.8 ± 16.0 years old. Elevated total cholesterol (TC) was observed in 173 (26.5%) cases with gout. Increased triglycerides (TG) and low-density lipoprotein (LDL-C) levels were observed in 242 (37.1%) cases and 270 (41.3%) cases with gout, individually. In contrast, elevated TC, TG and LDL-C levels were observed in 10 (15.9%) cases, 30 (47.6%) cases and 22 (34.9%) cases with hyperuricemia, individually. Significant differences were found in age, serum creatine, TC and erythrocyte sedimentation rate (ESR) between gout and asymptomatic hyperuricemia groups (p < 0.05). In patients with asymptomatic hyperuricemia, 12 (19.0%) patients had hypertension and 5 (7.9%) suffered from coronary heart diseases. Male (B = -112.7, p < 0.001), high-density lipoprotein (HDL-C) (B = -60.797, p = 0.013), body mass index (BMI) (B = 5.168, p = 0.024), age (B = -3.475, p = 0.006), age of hyperuricemia onset (B = 2.683, p = 0.032), and serum creatine (B = 0.534, p < 0.001) were predictors of sUA levels in gout patients (adjusted R2 = 28.7%). Conclusions Dyslipidemia is more commonly seen in patients with gout, compared to asymptomatic hyperuricemia. HDL-C is a protective predictor of sUA levels in gout.http://link.springer.com/article/10.1186/s12944-020-1197-yGoutHyperuricemiaHigh-density lipoproteinLipids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jing Liang Yutong Jiang Yefei Huang Wei Song Xiaomin Li Yulan Huang Jiayong Ou Qiujing Wei Jieruo Gu |
spellingShingle |
Jing Liang Yutong Jiang Yefei Huang Wei Song Xiaomin Li Yulan Huang Jiayong Ou Qiujing Wei Jieruo Gu The comparison of dyslipidemia and serum uric acid in patients with gout and asymptomatic hyperuricemia: a cross-sectional study Lipids in Health and Disease Gout Hyperuricemia High-density lipoprotein Lipids |
author_facet |
Jing Liang Yutong Jiang Yefei Huang Wei Song Xiaomin Li Yulan Huang Jiayong Ou Qiujing Wei Jieruo Gu |
author_sort |
Jing Liang |
title |
The comparison of dyslipidemia and serum uric acid in patients with gout and asymptomatic hyperuricemia: a cross-sectional study |
title_short |
The comparison of dyslipidemia and serum uric acid in patients with gout and asymptomatic hyperuricemia: a cross-sectional study |
title_full |
The comparison of dyslipidemia and serum uric acid in patients with gout and asymptomatic hyperuricemia: a cross-sectional study |
title_fullStr |
The comparison of dyslipidemia and serum uric acid in patients with gout and asymptomatic hyperuricemia: a cross-sectional study |
title_full_unstemmed |
The comparison of dyslipidemia and serum uric acid in patients with gout and asymptomatic hyperuricemia: a cross-sectional study |
title_sort |
comparison of dyslipidemia and serum uric acid in patients with gout and asymptomatic hyperuricemia: a cross-sectional study |
publisher |
BMC |
series |
Lipids in Health and Disease |
issn |
1476-511X |
publishDate |
2020-03-01 |
description |
Abstract Background Dyslipidemia often concurs with hyperuricemia. Our study was to discover different lipid levels of gout and asymptomatic hyperuricemia and the predictors of sUA (serum uric acid) levels. Methods A cross-sectional study was performed to collect demographic, clinical variables, comorbidities and laboratory testing in patients with gout and asymptomatic hyperuricemia. Group comparison was performed with Student’s t-test or Mann Whitney U test for continuous variables and chi-squared tests for categorical variables (Fisher’s exact test where appropriate) and to screen potential risk factors. Correlation of sUA levels with demographic and biochemical variables were performed by using correlation analysis. The variable with s p-value less than 0.20 during the group comparison or clinical relevance was introduced into the stepwise multiple regression model. Results Six hundred fifty-three patients with gout and 63 patients with asymptomatic hyperuricemia (> 420 μmol/L in male and > 360 μmol/L in female) were enrolled, including 553 (84.7%) males. The mean age was 47.8 ± 16.0 years old. Elevated total cholesterol (TC) was observed in 173 (26.5%) cases with gout. Increased triglycerides (TG) and low-density lipoprotein (LDL-C) levels were observed in 242 (37.1%) cases and 270 (41.3%) cases with gout, individually. In contrast, elevated TC, TG and LDL-C levels were observed in 10 (15.9%) cases, 30 (47.6%) cases and 22 (34.9%) cases with hyperuricemia, individually. Significant differences were found in age, serum creatine, TC and erythrocyte sedimentation rate (ESR) between gout and asymptomatic hyperuricemia groups (p < 0.05). In patients with asymptomatic hyperuricemia, 12 (19.0%) patients had hypertension and 5 (7.9%) suffered from coronary heart diseases. Male (B = -112.7, p < 0.001), high-density lipoprotein (HDL-C) (B = -60.797, p = 0.013), body mass index (BMI) (B = 5.168, p = 0.024), age (B = -3.475, p = 0.006), age of hyperuricemia onset (B = 2.683, p = 0.032), and serum creatine (B = 0.534, p < 0.001) were predictors of sUA levels in gout patients (adjusted R2 = 28.7%). Conclusions Dyslipidemia is more commonly seen in patients with gout, compared to asymptomatic hyperuricemia. HDL-C is a protective predictor of sUA levels in gout. |
topic |
Gout Hyperuricemia High-density lipoprotein Lipids |
url |
http://link.springer.com/article/10.1186/s12944-020-1197-y |
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