<i>Opuntia Ficus-Indica</i> L. Miller (Palma Forrageira) as an Alternative Source of Cellulose for Production of Pharmaceutical Dosage Forms and Biomaterials: Extraction and Characterization
Cellulose is among the top 5 excipients used in the pharmaceutical industry. It has been considered one of the main diluents used in conventional and modern dosage forms. Therefore, different raw materials of plant origin have been evaluated as potential alternative sources of cellulose. In this con...
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doaj-97ad1d8315594ac193df3f4a15864ced2020-11-25T01:33:26ZengMDPI AGPolymers2073-43602019-07-01117112410.3390/polym11071124polym11071124<i>Opuntia Ficus-Indica</i> L. Miller (Palma Forrageira) as an Alternative Source of Cellulose for Production of Pharmaceutical Dosage Forms and Biomaterials: Extraction and CharacterizationAmaro César Lima de Assis0Larissa Pereira Alves1João Paulo Tavares Malheiro2Alana Rafaela Albuquerque Barros3Edvânia Emannuelle Pinheiro-Santos4Eduardo Pereira de Azevedo5Harley da Silva Alves6João Augusto Oshiro-Junior7Bolívar Ponciano Goulart de Lima Damasceno8Graduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande 58429-500—PB, BrazilGraduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande 58429-500—PB, BrazilGraduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande 58429-500—PB, BrazilGraduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande 58429-500—PB, BrazilLaboratory of Development and Characterization of Pharmaceutical Products, Department of Pharmacy, State University of Paraíba, Campina Grande 58429-500—PB, BrazilGraduate Program of Biotechnology, Laureate International Universities—Universidade Potiguar, Natal 59056-000—RN, BrazilGraduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande 58429-500—PB, BrazilGraduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande 58429-500—PB, BrazilGraduate Program of Pharmaceutical Sciences, State University of Paraíba, Campina Grande 58429-500—PB, BrazilCellulose is among the top 5 excipients used in the pharmaceutical industry. It has been considered one of the main diluents used in conventional and modern dosage forms. Therefore, different raw materials of plant origin have been evaluated as potential alternative sources of cellulose. In this context, <i>Opuntia ficus-indica</i> L. Miller (palma forrageira), a plant of the cactus family that has physiological mechanisms that provide greater productivity with reduced water requirements, is an interesting and unexplored alternative for extracting cellulose. By using this source, we aim to decrease the extraction stages and increase the yields, which might result in a decreased cost for the industry and consequently for the consumer. The aim of this work was to investigate the use of <i>Opuntia ficus-indica</i> L. Miller as a new source for cellulose extraction, therefore providing an efficient, straight forward and low-cost method of cellulose II production. The extraction method is based on the oxidation of the lignins. The obtained cellulose was identified and characterized by spectroscopic methods (FTIR and NMR), X-ray diffraction, thermal analysis (TGA-DTG and DSC) and scanning electron microscopy. The results confirmed the identity of cellulose and its fibrous nature, which are promising characteristics for its use in the industry and a reasonable substrate for chemical modifications for the synthesis of cellulose II derivatives with different physicochemical properties that might be used in the production of drug delivery systems and biomaterials.https://www.mdpi.com/2073-4360/11/7/1124celullose<i>Opuntia ficus-indica</i> L. Miller (palma forrageira)pharmaceutical excipients |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amaro César Lima de Assis Larissa Pereira Alves João Paulo Tavares Malheiro Alana Rafaela Albuquerque Barros Edvânia Emannuelle Pinheiro-Santos Eduardo Pereira de Azevedo Harley da Silva Alves João Augusto Oshiro-Junior Bolívar Ponciano Goulart de Lima Damasceno |
spellingShingle |
Amaro César Lima de Assis Larissa Pereira Alves João Paulo Tavares Malheiro Alana Rafaela Albuquerque Barros Edvânia Emannuelle Pinheiro-Santos Eduardo Pereira de Azevedo Harley da Silva Alves João Augusto Oshiro-Junior Bolívar Ponciano Goulart de Lima Damasceno <i>Opuntia Ficus-Indica</i> L. Miller (Palma Forrageira) as an Alternative Source of Cellulose for Production of Pharmaceutical Dosage Forms and Biomaterials: Extraction and Characterization Polymers celullose <i>Opuntia ficus-indica</i> L. Miller (palma forrageira) pharmaceutical excipients |
author_facet |
Amaro César Lima de Assis Larissa Pereira Alves João Paulo Tavares Malheiro Alana Rafaela Albuquerque Barros Edvânia Emannuelle Pinheiro-Santos Eduardo Pereira de Azevedo Harley da Silva Alves João Augusto Oshiro-Junior Bolívar Ponciano Goulart de Lima Damasceno |
author_sort |
Amaro César Lima de Assis |
title |
<i>Opuntia Ficus-Indica</i> L. Miller (Palma Forrageira) as an Alternative Source of Cellulose for Production of Pharmaceutical Dosage Forms and Biomaterials: Extraction and Characterization |
title_short |
<i>Opuntia Ficus-Indica</i> L. Miller (Palma Forrageira) as an Alternative Source of Cellulose for Production of Pharmaceutical Dosage Forms and Biomaterials: Extraction and Characterization |
title_full |
<i>Opuntia Ficus-Indica</i> L. Miller (Palma Forrageira) as an Alternative Source of Cellulose for Production of Pharmaceutical Dosage Forms and Biomaterials: Extraction and Characterization |
title_fullStr |
<i>Opuntia Ficus-Indica</i> L. Miller (Palma Forrageira) as an Alternative Source of Cellulose for Production of Pharmaceutical Dosage Forms and Biomaterials: Extraction and Characterization |
title_full_unstemmed |
<i>Opuntia Ficus-Indica</i> L. Miller (Palma Forrageira) as an Alternative Source of Cellulose for Production of Pharmaceutical Dosage Forms and Biomaterials: Extraction and Characterization |
title_sort |
<i>opuntia ficus-indica</i> l. miller (palma forrageira) as an alternative source of cellulose for production of pharmaceutical dosage forms and biomaterials: extraction and characterization |
publisher |
MDPI AG |
series |
Polymers |
issn |
2073-4360 |
publishDate |
2019-07-01 |
description |
Cellulose is among the top 5 excipients used in the pharmaceutical industry. It has been considered one of the main diluents used in conventional and modern dosage forms. Therefore, different raw materials of plant origin have been evaluated as potential alternative sources of cellulose. In this context, <i>Opuntia ficus-indica</i> L. Miller (palma forrageira), a plant of the cactus family that has physiological mechanisms that provide greater productivity with reduced water requirements, is an interesting and unexplored alternative for extracting cellulose. By using this source, we aim to decrease the extraction stages and increase the yields, which might result in a decreased cost for the industry and consequently for the consumer. The aim of this work was to investigate the use of <i>Opuntia ficus-indica</i> L. Miller as a new source for cellulose extraction, therefore providing an efficient, straight forward and low-cost method of cellulose II production. The extraction method is based on the oxidation of the lignins. The obtained cellulose was identified and characterized by spectroscopic methods (FTIR and NMR), X-ray diffraction, thermal analysis (TGA-DTG and DSC) and scanning electron microscopy. The results confirmed the identity of cellulose and its fibrous nature, which are promising characteristics for its use in the industry and a reasonable substrate for chemical modifications for the synthesis of cellulose II derivatives with different physicochemical properties that might be used in the production of drug delivery systems and biomaterials. |
topic |
celullose <i>Opuntia ficus-indica</i> L. Miller (palma forrageira) pharmaceutical excipients |
url |
https://www.mdpi.com/2073-4360/11/7/1124 |
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