Spatial navigational strategies correlate with grey matter in the hippocampus of healthy older adults tested in a virtual maze

• Main Authors: Kyoko eKonishi, Veronique D Bohbot
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2013-02-01
• Series: Frontiers in Aging Neuroscience
• Subjects: Aging; Hippocampus; spatial memory; navigation; radial maze
• Online Access: http://journal.frontiersin.org/Journal/10.3389/fnagi.2013.00001/full

Healthy young adults use different strategies when navigating in a virtual maze. Spatial strategies involve using environmental landmarks while response strategies involve executing a series of movements from specific stimuli. Neuroimaging studies previously confirmed that people who use spatial strategies show increased activity and grey matter in the hippocampus, while those who use response strategies show increased activity and grey matter in caudate nucleus (Bohbot, Lerch, Thorndycraft, Iaria, & Zijdenbos, 2007; Iaria, Petrides, Dagher, Pike, & Bohbot, 2003). A growing number of studies report that cognitive decline that occurs with normal aging is correlated with a decrease in volume of the hippocampus. Here, we used voxel-based morphometry to examine whether spatial strategies in aging are correlated with greater grey matter in the hippocampus, as found in our previous study with healthy young participants. Forty-five healthy older adults were tested on a virtual navigation task that allows spatial and response strategies. All participants learn the task to criterion after which a special probe trial that assesses spatial and response strategies is given. Results show that spontaneous spatial memory strategies, and not performance on the navigation task, positively correlate with grey matter in the hippocampus. Since numerous studies have shown that a decrease in the volume of the hippocampus correlates with cognitive deficits during normal aging and increases the risks of ensuing dementia, the current results suggest that older people who use their spatial memory strategies in their everyday lives may have increased grey matter in the hippocampus and enhance their probability of healthy and successful aging.