Adipokines and Hepatic Insulin Resistance

Adipokines and Hepatic Insulin Resistance

Obesity is a major risk factor for insulin resistance and type 2 diabetes. Adipose tissue is now considered to be an active endocrine organ that secretes various adipokines such as adiponectin, leptin, resistin, tumour necrosis factor-α, and interleukin-6. Recent studies have shown that these factor...

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Main Authors: Yu Li, Lin Ding, Waseem Hassan, Daoud Abdelkader, Jing Shang
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2013/170532
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spelling doaj-97b1e35180fb45e2ab5cc3b951018cfd2020-11-24T22:25:04ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/170532170532Adipokines and Hepatic Insulin ResistanceYu Li0Lin Ding1Waseem Hassan2Daoud Abdelkader3Jing Shang4National Center for Drug Screening and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Jiangsu Province 210009, ChinaNational Center for Drug Screening and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Jiangsu Province 210009, ChinaNational Center for Drug Screening and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Jiangsu Province 210009, ChinaNational Center for Drug Screening and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Jiangsu Province 210009, ChinaNational Center for Drug Screening and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Jiangsu Province 210009, ChinaObesity is a major risk factor for insulin resistance and type 2 diabetes. Adipose tissue is now considered to be an active endocrine organ that secretes various adipokines such as adiponectin, leptin, resistin, tumour necrosis factor-α, and interleukin-6. Recent studies have shown that these factors might provide a molecular link between increased adiposity and impaired insulin sensitivity. Since hepatic insulin resistance plays the key role in the whole body insulin resistance, clarification of the regulatory processes about hepatic insulin resistance by adipokines in rodents and human would seem essential in order to understand the mechanism of type 2 diabetes and for developing novel therapeutic strategies to treat it.http://dx.doi.org/10.1155/2013/170532
collection DOAJ
language English
format Article
sources DOAJ
author Yu Li
Lin Ding
Waseem Hassan
Daoud Abdelkader
Jing Shang
spellingShingle Yu Li
Lin Ding
Waseem Hassan
Daoud Abdelkader
Jing Shang
Adipokines and Hepatic Insulin Resistance
Journal of Diabetes Research
author_facet Yu Li
Lin Ding
Waseem Hassan
Daoud Abdelkader
Jing Shang
author_sort Yu Li
title Adipokines and Hepatic Insulin Resistance
title_short Adipokines and Hepatic Insulin Resistance
title_full Adipokines and Hepatic Insulin Resistance
title_fullStr Adipokines and Hepatic Insulin Resistance
title_full_unstemmed Adipokines and Hepatic Insulin Resistance
title_sort adipokines and hepatic insulin resistance
publisher Hindawi Limited
series Journal of Diabetes Research
issn 2314-6745
2314-6753
publishDate 2013-01-01
description Obesity is a major risk factor for insulin resistance and type 2 diabetes. Adipose tissue is now considered to be an active endocrine organ that secretes various adipokines such as adiponectin, leptin, resistin, tumour necrosis factor-α, and interleukin-6. Recent studies have shown that these factors might provide a molecular link between increased adiposity and impaired insulin sensitivity. Since hepatic insulin resistance plays the key role in the whole body insulin resistance, clarification of the regulatory processes about hepatic insulin resistance by adipokines in rodents and human would seem essential in order to understand the mechanism of type 2 diabetes and for developing novel therapeutic strategies to treat it.
url http://dx.doi.org/10.1155/2013/170532
work_keys_str_mv AT yuli adipokinesandhepaticinsulinresistance
AT linding adipokinesandhepaticinsulinresistance
AT waseemhassan adipokinesandhepaticinsulinresistance
AT daoudabdelkader adipokinesandhepaticinsulinresistance
AT jingshang adipokinesandhepaticinsulinresistance
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