Maternal Immunization and Antenatal Care Situation Analysis (MIACSA) study protocol: a multiregional, cross-sectional analysis of maternal immunization delivery strategies to reduce maternal and neonatal morbidity and mortality

• Main Authors: Theresa Diaz, Pradeep Haldar, Nathalie Roos, Philipp Lambach, Carsten Mantel, Elizabeth Mason, Flor M Muñoz, Michelle Giles, Allisyn Moran, Joachim Hombach, Michelle L Giles, Mercy Ahun, Martina Baye, Matthews Mathai, Sonja Mertens, Jayani Pathirana, Sarah Rendell, Emily Wootton, Laura Nic Lochlainn, Ahmadu Yakubu, And Sara Rendell
• Format: Article
• Language: English
• Published: BMJ Publishing Group 2019-06-01
• Series: BMJ Open
• Online Access: https://bmjopen.bmj.com/content/9/6/e024449.full

IntroductionMaternal immunization (MI) with tetanus toxoid containing vaccine, is a safe and cost-effective way of preventing neonatal tetanus. Given the prospect of introducing new maternal vaccines in the near future, it is essential to identify and understand current policies, practices and unmet needs for introducing and/or scaling up MI in low-income and middle-income countries (LMICs).Methods and analysisThe Maternal Immunization and Antenatal Care Situation Analysis (MIACSA) is a mixed methods, cross-sectional study that will collect data in four phases: (1) a review of global databases for selected health indicators in 136 LMICs; (2) a structured online survey directed at Maternal, Newborn and Child Health and Expanded Programme on Immunization focal points in all 136 LMICs; (3) semistructured telephone interviews of 30 selected LMICs and (4) 10 week-long country visits, including key informant interviews, health facility visits and focus group discussions. The principal analyses will assess correlations between the various aspects of MI delivery strategies and proxy measures of health systems performance related to vaccine-preventable disease control. The primary outcome will be a typology of existing MI delivery models, and secondary outcomes will include country profiles of child and maternal health indicators, and a MI gaps and needs analysis.Ethics and disseminationThe protocol was approved by the WHO Ethics Review Committee (ERC.0002908). The results will be made available in a project report and submitted for publication in peer-reviewed journals that will be shared broadly among global health decision-makers, researchers, product developers and country-level stakeholders.