Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma

Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma

Long noncoding RNAs (lncRNAs) have been attracting immense research interests. However, only a handful of lncRNAs had been thoroughly characterized. They were involved in fundamental cellular processes including regulation of gene expression at epigenetics as well as tumorogenesis. In this paper, we...

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Main Authors: Guangbing Li, Haohai Zhang, Xueshuai Wan, Xiaobo Yang, Chengpei Zhu, Anqiang Wang, Lian He, Ruoyu Miao, Shuguang Chen, Haitao Zhao
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/780521
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spelling doaj-97c8e56f7b464060a42888224242c9422020-11-24T23:16:08ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/780521780521Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular CarcinomaGuangbing Li0Haohai Zhang1Xueshuai Wan2Xiaobo Yang3Chengpei Zhu4Anqiang Wang5Lian He6Ruoyu Miao7Shuguang Chen8Haitao Zhao9Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, ChinaDepartment of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, ChinaDepartment of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, ChinaDepartment of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, ChinaDepartment of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, ChinaDepartment of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, ChinaDepartment of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, ChinaDepartment of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, ChinaDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, ChinaDepartment of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, ChinaLong noncoding RNAs (lncRNAs) have been attracting immense research interests. However, only a handful of lncRNAs had been thoroughly characterized. They were involved in fundamental cellular processes including regulation of gene expression at epigenetics as well as tumorogenesis. In this paper, we give a systematic and comprehensive review of existing literature about lncRNA involvement in hepatocellular carcinoma. This review exhibited that lncRNAs played important roles in tumorigenesis and subsequent prognosis and metastasis of hepatocellular carcinoma and elucidated the role of some specific lncRNAs such as MALAT1 and HOTAIR in the pathophysiology of hepatocellular carcinoma and their potential of being therapeutic targets.http://dx.doi.org/10.1155/2014/780521
collection DOAJ
language English
format Article
sources DOAJ
author Guangbing Li
Haohai Zhang
Xueshuai Wan
Xiaobo Yang
Chengpei Zhu
Anqiang Wang
Lian He
Ruoyu Miao
Shuguang Chen
Haitao Zhao
spellingShingle Guangbing Li
Haohai Zhang
Xueshuai Wan
Xiaobo Yang
Chengpei Zhu
Anqiang Wang
Lian He
Ruoyu Miao
Shuguang Chen
Haitao Zhao
Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma
BioMed Research International
author_facet Guangbing Li
Haohai Zhang
Xueshuai Wan
Xiaobo Yang
Chengpei Zhu
Anqiang Wang
Lian He
Ruoyu Miao
Shuguang Chen
Haitao Zhao
author_sort Guangbing Li
title Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma
title_short Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma
title_full Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma
title_fullStr Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma
title_full_unstemmed Long Noncoding RNA Plays a Key Role in Metastasis and Prognosis of Hepatocellular Carcinoma
title_sort long noncoding rna plays a key role in metastasis and prognosis of hepatocellular carcinoma
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2014-01-01
description Long noncoding RNAs (lncRNAs) have been attracting immense research interests. However, only a handful of lncRNAs had been thoroughly characterized. They were involved in fundamental cellular processes including regulation of gene expression at epigenetics as well as tumorogenesis. In this paper, we give a systematic and comprehensive review of existing literature about lncRNA involvement in hepatocellular carcinoma. This review exhibited that lncRNAs played important roles in tumorigenesis and subsequent prognosis and metastasis of hepatocellular carcinoma and elucidated the role of some specific lncRNAs such as MALAT1 and HOTAIR in the pathophysiology of hepatocellular carcinoma and their potential of being therapeutic targets.
url http://dx.doi.org/10.1155/2014/780521
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