Minimizing off-Target Mutagenesis Risks Caused by Programmable Nucleases
Programmable nucleases, such as zinc finger nucleases (ZFNs), transcription activator like effector nucleases (TALENs), and clustered regularly interspersed short palindromic repeats associated protein-9 (CRISPR-Cas9), hold tremendous potential for applications in the clinical setting to treat genet...
Main Authors: | Kentaro Ishida, Peter Gee, Akitsu Hotta |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2015-10-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | http://www.mdpi.com/1422-0067/16/10/24751 |
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