Evolution of thermal response properties in a cold-activated TRP channel.

Evolution of thermal response properties in a cold-activated TRP channel.

Animals sense changes in ambient temperature irrespective of whether core body temperature is internally maintained (homeotherms) or subject to environmental variation (poikilotherms). Here we show that a cold-sensitive ion channel, TRPM8, displays dramatically different thermal activation ranges in...

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Bibliographic Details
Main Authors: Benjamin R Myers, Yaron M Sigal, David Julius
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2683941?pdf=render
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spelling doaj-97decc2a8ab349f29506a5321b26ffe72020-11-24T21:49:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032009-01-0145e574110.1371/journal.pone.0005741Evolution of thermal response properties in a cold-activated TRP channel.Benjamin R MyersYaron M SigalDavid JuliusAnimals sense changes in ambient temperature irrespective of whether core body temperature is internally maintained (homeotherms) or subject to environmental variation (poikilotherms). Here we show that a cold-sensitive ion channel, TRPM8, displays dramatically different thermal activation ranges in frogs versus mammals or birds, consistent with variations in these species' cutaneous and core body temperatures. Thus, somatosensory receptors are not static through evolution, but show functional diversity reflecting the characteristics of an organism's ecological niche.http://europepmc.org/articles/PMC2683941?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Benjamin R Myers
Yaron M Sigal
David Julius
spellingShingle Benjamin R Myers
Yaron M Sigal
David Julius
Evolution of thermal response properties in a cold-activated TRP channel.
PLoS ONE
author_facet Benjamin R Myers
Yaron M Sigal
David Julius
author_sort Benjamin R Myers
title Evolution of thermal response properties in a cold-activated TRP channel.
title_short Evolution of thermal response properties in a cold-activated TRP channel.
title_full Evolution of thermal response properties in a cold-activated TRP channel.
title_fullStr Evolution of thermal response properties in a cold-activated TRP channel.
title_full_unstemmed Evolution of thermal response properties in a cold-activated TRP channel.
title_sort evolution of thermal response properties in a cold-activated trp channel.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2009-01-01
description Animals sense changes in ambient temperature irrespective of whether core body temperature is internally maintained (homeotherms) or subject to environmental variation (poikilotherms). Here we show that a cold-sensitive ion channel, TRPM8, displays dramatically different thermal activation ranges in frogs versus mammals or birds, consistent with variations in these species' cutaneous and core body temperatures. Thus, somatosensory receptors are not static through evolution, but show functional diversity reflecting the characteristics of an organism's ecological niche.
url http://europepmc.org/articles/PMC2683941?pdf=render
work_keys_str_mv AT benjaminrmyers evolutionofthermalresponsepropertiesinacoldactivatedtrpchannel
AT yaronmsigal evolutionofthermalresponsepropertiesinacoldactivatedtrpchannel
AT davidjulius evolutionofthermalresponsepropertiesinacoldactivatedtrpchannel
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