Ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastases
Abstract Background Myosteatosis has been associated with shorter overall survival in cancer patients. The increase in ectopic fat might not be limited to skeletal muscle only and might also extend to other sites such as the liver, resulting in non‐alcoholic fatty liver disease (NAFLD). In this stud...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2021-08-01
|
Series: | Journal of Cachexia, Sarcopenia and Muscle |
Subjects: | |
Online Access: | https://doi.org/10.1002/jcsm.12723 |
id |
doaj-97e069d7adc345dabb843c826c2e9279 |
---|---|
record_format |
Article |
spelling |
doaj-97e069d7adc345dabb843c826c2e92792021-08-09T05:46:55ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092021-08-0112498399210.1002/jcsm.12723Ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastasesDavid P.J. vanDijk0Junfang Zhao1Katrin Kemter2Vickie E. Baracos3Cornelis H.C. Dejong4Sander S. Rensen5Steven W.M. Olde Damink6Department of Surgery Maastricht University Medical Centre Maastricht The NetherlandsDepartment of Surgery Maastricht University Medical Centre Maastricht The NetherlandsDepartment of Surgery Maastricht University Medical Centre Maastricht The NetherlandsDepartment of Oncology University of Alberta Edmonton Alberta CanadaDepartment of Surgery Maastricht University Medical Centre Maastricht The NetherlandsDepartment of Surgery Maastricht University Medical Centre Maastricht The NetherlandsDepartment of Surgery Maastricht University Medical Centre Maastricht The NetherlandsAbstract Background Myosteatosis has been associated with shorter overall survival in cancer patients. The increase in ectopic fat might not be limited to skeletal muscle only and might also extend to other sites such as the liver, resulting in non‐alcoholic fatty liver disease (NAFLD). In this study, we assessed the relationship between myosteatosis and NAFLD and their association with overall survival in patients with colorectal liver metastases undergoing partial hepatectomy. Methods Patients were selected from a prospective cohort of 289 consecutive patients with colorectal liver metastases. All patients with a preoperative computed tomography (CT)‐scan and liver biopsy obtained during surgery were included. If available a second pre‐operative CT scan was used to calculate changes in body composition over time. Muscle radiation attenuation was defined as the average Hounsfield units on CT of all muscle tissue at the L3 level. Liver biopsies were graded by a liver pathologist using the steatosis, activity, and fibrosis scoring system for NAFLD. Results Two‐hundred and eighteen patients had an available liver biopsy of which 131 patients had two available pre‐operative CT scans with an average time interval of 3.2 months. One‐hundred and thirty‐five (62%) biopsies were classified as NAFLD. In multivariable Cox‐regression analysis, NAFLD [hazard ratio (HR): 1.8, 95%‐confidence interval (CI) 1.0–3.0, P = 0.037], increase in myosteatosis (HR 1.8, 95%‐CI 1.1–2.9, P = 0.018), and skeletal muscle loss (HR 1.7, 95%‐CI 1.0–2.9, P = 0.035) were independently associated with shorter overall survival while high visceral adipose tissue fat content was associated with longer overall survival (HR: 0.7, 95%‐CI 0.5–0.9, P = 0.014). Conclusions Ectopic fat content of liver as well as skeletal muscle tissue is independently associated with shorter overall survival in patients with colorectal liver metastases, while increased visceral adipose tissue fat content is associated with longer overall survival.https://doi.org/10.1002/jcsm.12723Body compositionNon‐alcoholic fatty liver diseaseSkeletal muscle lossSarcopeniaMyosteatosisColorectal liver metastases |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David P.J. vanDijk Junfang Zhao Katrin Kemter Vickie E. Baracos Cornelis H.C. Dejong Sander S. Rensen Steven W.M. Olde Damink |
spellingShingle |
David P.J. vanDijk Junfang Zhao Katrin Kemter Vickie E. Baracos Cornelis H.C. Dejong Sander S. Rensen Steven W.M. Olde Damink Ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastases Journal of Cachexia, Sarcopenia and Muscle Body composition Non‐alcoholic fatty liver disease Skeletal muscle loss Sarcopenia Myosteatosis Colorectal liver metastases |
author_facet |
David P.J. vanDijk Junfang Zhao Katrin Kemter Vickie E. Baracos Cornelis H.C. Dejong Sander S. Rensen Steven W.M. Olde Damink |
author_sort |
David P.J. vanDijk |
title |
Ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastases |
title_short |
Ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastases |
title_full |
Ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastases |
title_fullStr |
Ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastases |
title_full_unstemmed |
Ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastases |
title_sort |
ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastases |
publisher |
Wiley |
series |
Journal of Cachexia, Sarcopenia and Muscle |
issn |
2190-5991 2190-6009 |
publishDate |
2021-08-01 |
description |
Abstract Background Myosteatosis has been associated with shorter overall survival in cancer patients. The increase in ectopic fat might not be limited to skeletal muscle only and might also extend to other sites such as the liver, resulting in non‐alcoholic fatty liver disease (NAFLD). In this study, we assessed the relationship between myosteatosis and NAFLD and their association with overall survival in patients with colorectal liver metastases undergoing partial hepatectomy. Methods Patients were selected from a prospective cohort of 289 consecutive patients with colorectal liver metastases. All patients with a preoperative computed tomography (CT)‐scan and liver biopsy obtained during surgery were included. If available a second pre‐operative CT scan was used to calculate changes in body composition over time. Muscle radiation attenuation was defined as the average Hounsfield units on CT of all muscle tissue at the L3 level. Liver biopsies were graded by a liver pathologist using the steatosis, activity, and fibrosis scoring system for NAFLD. Results Two‐hundred and eighteen patients had an available liver biopsy of which 131 patients had two available pre‐operative CT scans with an average time interval of 3.2 months. One‐hundred and thirty‐five (62%) biopsies were classified as NAFLD. In multivariable Cox‐regression analysis, NAFLD [hazard ratio (HR): 1.8, 95%‐confidence interval (CI) 1.0–3.0, P = 0.037], increase in myosteatosis (HR 1.8, 95%‐CI 1.1–2.9, P = 0.018), and skeletal muscle loss (HR 1.7, 95%‐CI 1.0–2.9, P = 0.035) were independently associated with shorter overall survival while high visceral adipose tissue fat content was associated with longer overall survival (HR: 0.7, 95%‐CI 0.5–0.9, P = 0.014). Conclusions Ectopic fat content of liver as well as skeletal muscle tissue is independently associated with shorter overall survival in patients with colorectal liver metastases, while increased visceral adipose tissue fat content is associated with longer overall survival. |
topic |
Body composition Non‐alcoholic fatty liver disease Skeletal muscle loss Sarcopenia Myosteatosis Colorectal liver metastases |
url |
https://doi.org/10.1002/jcsm.12723 |
work_keys_str_mv |
AT davidpjvandijk ectopicfatinliverandskeletalmuscleisassociatedwithshorteroverallsurvivalinpatientswithcolorectallivermetastases AT junfangzhao ectopicfatinliverandskeletalmuscleisassociatedwithshorteroverallsurvivalinpatientswithcolorectallivermetastases AT katrinkemter ectopicfatinliverandskeletalmuscleisassociatedwithshorteroverallsurvivalinpatientswithcolorectallivermetastases AT vickieebaracos ectopicfatinliverandskeletalmuscleisassociatedwithshorteroverallsurvivalinpatientswithcolorectallivermetastases AT cornelishcdejong ectopicfatinliverandskeletalmuscleisassociatedwithshorteroverallsurvivalinpatientswithcolorectallivermetastases AT sandersrensen ectopicfatinliverandskeletalmuscleisassociatedwithshorteroverallsurvivalinpatientswithcolorectallivermetastases AT stevenwmoldedamink ectopicfatinliverandskeletalmuscleisassociatedwithshorteroverallsurvivalinpatientswithcolorectallivermetastases |
_version_ |
1721215231395364864 |