Primary pleural haemangioendothelioma in an Italian female patient: a case report and review of the literature

Primary epithelioid haemangioendothelioma (EHE) of the pleura is a rare vascular tumour that occurs mainly in men. Pleural effusion and thickening are the most common clinical presentations. A 58 year old female, nonsmoking patient presented to us with dry cough, dyspnoea and left chest pain for sev...

Full description

Bibliographic Details
Main Authors: M. Bocchino, E. Barra, F. Lassandro, F. Ranieri, R. Muto, G. Rea
Format: Article
Language:English
Published: PAGEPress Publications 2016-01-01
Series:Monaldi Archives for Chest Disease
Subjects:
Online Access:https://www.monaldi-archives.org/index.php/macd/article/view/298
id doaj-97e2e39385354695b5a4351e79fc51e7
record_format Article
spelling doaj-97e2e39385354695b5a4351e79fc51e72020-11-24T22:01:43ZengPAGEPress PublicationsMonaldi Archives for Chest Disease1122-06432532-52642016-01-0173310.4081/monaldi.2010.298Primary pleural haemangioendothelioma in an Italian female patient: a case report and review of the literatureM. Bocchino0E. Barra1F. Lassandro2F. Ranieri3R. Muto4G. Rea5Department of Clinical and Experimental Medicine, “Federico II” University, NaplesDepartment of Pathology, Monaldi Hospital, NaplesDepartment of Radiology, Monaldi Hospital, NaplesDepartment of Radiology “Magrassi-Lanzara”, Second University of Naples, NaplesDepartment of Radiology, Monaldi Hospital, NaplesDepartment of Radiology, Monaldi Hospital, NaplesPrimary epithelioid haemangioendothelioma (EHE) of the pleura is a rare vascular tumour that occurs mainly in men. Pleural effusion and thickening are the most common clinical presentations. A 58 year old female, nonsmoking patient presented to us with dry cough, dyspnoea and left chest pain for several weeks (no asbestos exposure). Standard chest X-ray and contrast enhanced multislice computed tomography revealed a large-size lobulated mass originating from the pleura which was diagnosed as primary pleural haemangioendothelioma (PHE) by histology and immunohistochemistry (reactivity for vimentin, CD31, CD34, Factor VIII and ulex europeaus). No metastases were detected. The patient refused treatment and died three months later due to the onset of acute and progressive respiratory failure. Despite the lack of highgrade malignancy, primary PHE displays a poor prognosis while curative therapies are actually not available. To our knowledge, this is the first case of primary PHE in a female patient occurring in Italy and the third one to have been reported in English literature. Difficulties in diagnosis and treatment management are discussed below.https://www.monaldi-archives.org/index.php/macd/article/view/298HaemangioendotheliomaImmunohistochemistryPleura
collection DOAJ
language English
format Article
sources DOAJ
author M. Bocchino
E. Barra
F. Lassandro
F. Ranieri
R. Muto
G. Rea
spellingShingle M. Bocchino
E. Barra
F. Lassandro
F. Ranieri
R. Muto
G. Rea
Primary pleural haemangioendothelioma in an Italian female patient: a case report and review of the literature
Monaldi Archives for Chest Disease
Haemangioendothelioma
Immunohistochemistry
Pleura
author_facet M. Bocchino
E. Barra
F. Lassandro
F. Ranieri
R. Muto
G. Rea
author_sort M. Bocchino
title Primary pleural haemangioendothelioma in an Italian female patient: a case report and review of the literature
title_short Primary pleural haemangioendothelioma in an Italian female patient: a case report and review of the literature
title_full Primary pleural haemangioendothelioma in an Italian female patient: a case report and review of the literature
title_fullStr Primary pleural haemangioendothelioma in an Italian female patient: a case report and review of the literature
title_full_unstemmed Primary pleural haemangioendothelioma in an Italian female patient: a case report and review of the literature
title_sort primary pleural haemangioendothelioma in an italian female patient: a case report and review of the literature
publisher PAGEPress Publications
series Monaldi Archives for Chest Disease
issn 1122-0643
2532-5264
publishDate 2016-01-01
description Primary epithelioid haemangioendothelioma (EHE) of the pleura is a rare vascular tumour that occurs mainly in men. Pleural effusion and thickening are the most common clinical presentations. A 58 year old female, nonsmoking patient presented to us with dry cough, dyspnoea and left chest pain for several weeks (no asbestos exposure). Standard chest X-ray and contrast enhanced multislice computed tomography revealed a large-size lobulated mass originating from the pleura which was diagnosed as primary pleural haemangioendothelioma (PHE) by histology and immunohistochemistry (reactivity for vimentin, CD31, CD34, Factor VIII and ulex europeaus). No metastases were detected. The patient refused treatment and died three months later due to the onset of acute and progressive respiratory failure. Despite the lack of highgrade malignancy, primary PHE displays a poor prognosis while curative therapies are actually not available. To our knowledge, this is the first case of primary PHE in a female patient occurring in Italy and the third one to have been reported in English literature. Difficulties in diagnosis and treatment management are discussed below.
topic Haemangioendothelioma
Immunohistochemistry
Pleura
url https://www.monaldi-archives.org/index.php/macd/article/view/298
work_keys_str_mv AT mbocchino primarypleuralhaemangioendotheliomainanitalianfemalepatientacasereportandreviewoftheliterature
AT ebarra primarypleuralhaemangioendotheliomainanitalianfemalepatientacasereportandreviewoftheliterature
AT flassandro primarypleuralhaemangioendotheliomainanitalianfemalepatientacasereportandreviewoftheliterature
AT franieri primarypleuralhaemangioendotheliomainanitalianfemalepatientacasereportandreviewoftheliterature
AT rmuto primarypleuralhaemangioendotheliomainanitalianfemalepatientacasereportandreviewoftheliterature
AT grea primarypleuralhaemangioendotheliomainanitalianfemalepatientacasereportandreviewoftheliterature
_version_ 1725838922890608640