Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs an...
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Hindawi Limited
2015-01-01
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Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2015/318364 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mercedes García-Bermúdez Raquel López-Mejías Fernanda Genre Santos Castañeda Alfonso Corrales Javier Llorca Carlos González-Juanatey Begoña Ubilla José A. Miranda-Filloy Trinitario Pina Carmen Gómez-Vaquero Luis Rodríguez-Rodríguez Benjamín Fernández-Gutiérrez Alejandro Balsa Dora Pascual-Salcedo Francisco J. López-Longo Patricia Carreira Ricardo Blanco Javier Martín Miguel A. González-Gay |
spellingShingle |
Mercedes García-Bermúdez Raquel López-Mejías Fernanda Genre Santos Castañeda Alfonso Corrales Javier Llorca Carlos González-Juanatey Begoña Ubilla José A. Miranda-Filloy Trinitario Pina Carmen Gómez-Vaquero Luis Rodríguez-Rodríguez Benjamín Fernández-Gutiérrez Alejandro Balsa Dora Pascual-Salcedo Francisco J. López-Longo Patricia Carreira Ricardo Blanco Javier Martín Miguel A. González-Gay Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis BioMed Research International |
author_facet |
Mercedes García-Bermúdez Raquel López-Mejías Fernanda Genre Santos Castañeda Alfonso Corrales Javier Llorca Carlos González-Juanatey Begoña Ubilla José A. Miranda-Filloy Trinitario Pina Carmen Gómez-Vaquero Luis Rodríguez-Rodríguez Benjamín Fernández-Gutiérrez Alejandro Balsa Dora Pascual-Salcedo Francisco J. López-Longo Patricia Carreira Ricardo Blanco Javier Martín Miguel A. González-Gay |
author_sort |
Mercedes García-Bermúdez |
title |
Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis |
title_short |
Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis |
title_full |
Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis |
title_fullStr |
Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis |
title_full_unstemmed |
Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid Arthritis |
title_sort |
lack of association between jak3 gene polymorphisms and cardiovascular disease in spanish patients with rheumatoid arthritis |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Rheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms in JAK3 gene have been associated with CV events in incident dialysis patients. Therefore, the aim of this study was to assess the potential role of JAK3 polymorphisms in the development of CV disease in patients with RA. 2136 Spanish RA patients were genotyped for the rs3212780 and rs3212752 JAK3 gene polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 539 of these patients by carotid ultrasonography (US). No statistically significant differences were found when each polymorphism was assessed according to carotid intima-media thickness values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV events after adjusting for potential confounders. In conclusion, our results do not confirm association between JAK3 polymorphisms and CV disease in RA. |
url |
http://dx.doi.org/10.1155/2015/318364 |
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doaj-97ee54cdef1b4a1c88108ab6ece3133d2020-11-24T23:31:04ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/318364318364Lack of Association between JAK3 Gene Polymorphisms and Cardiovascular Disease in Spanish Patients with Rheumatoid ArthritisMercedes García-Bermúdez0Raquel López-Mejías1Fernanda Genre2Santos Castañeda3Alfonso Corrales4Javier Llorca5Carlos González-Juanatey6Begoña Ubilla7José A. Miranda-Filloy8Trinitario Pina9Carmen Gómez-Vaquero10Luis Rodríguez-Rodríguez11Benjamín Fernández-Gutiérrez12Alejandro Balsa13Dora Pascual-Salcedo14Francisco J. López-Longo15Patricia Carreira16Ricardo Blanco17Javier Martín18Miguel A. González-Gay19Institute of Parasitología and Biomedicina López-Neyra, IPBLN-CSIC, 18016 Granada, SpainEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Disease, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla s/n, 39008 Santander, SpainEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Disease, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla s/n, 39008 Santander, SpainRheumatology Department, Hospital Universitario La Princesa, IIS-Princesa, 28006 Madrid, SpainEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Disease, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla s/n, 39008 Santander, SpainDepartment of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiology and Public Health (CIBERESP), IDIVAL, 39011 Santander, SpainCardiology Division, Hospital Universitario Lucus Augusti, 27003 Lugo, SpainEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Disease, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla s/n, 39008 Santander, SpainDivision of Rheumatology, Hospital Universitario Lucus Augusti, 27003 Lugo, SpainEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Disease, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla s/n, 39008 Santander, SpainDepartment of Rheumatology, Hospital Universitario Bellvitge, 08907 Barcelona, SpainDepartment of Rheumatology, Hospital Clínico San Carlos, 28040 Madrid, SpainDepartment of Rheumatology, Hospital Clínico San Carlos, 28040 Madrid, SpainDepartment of Rheumatology, Hospital Universitario La Paz, 28046 Madrid, SpainDepartment of Rheumatology, Hospital Universitario La Paz, 28046 Madrid, SpainDepartment of Rheumatology, Hospital General Universitario Gregorio Marañón, 28007 Madrid, SpainDepartment of Rheumatology, Hospital Universitario 12 de Octubre, 28041 Madrid, SpainEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Disease, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla s/n, 39008 Santander, SpainInstitute of Parasitología and Biomedicina López-Neyra, IPBLN-CSIC, 18016 Granada, SpainEpidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Disease, Rheumatology Division, Hospital Universitario Marqués de Valdecilla, IDIVAL, Avenida de Valdecilla s/n, 39008 Santander, SpainRheumatoid arthritis (RA) is a polygenic disease associated with accelerated atherosclerosis and increased cardiovascular (CV) mortality. JAK/STAT signalling pathway is involved in autoimmune diseases and in the atherosclerotic process. JAK3 is a highly promising target for immunomodulatory drugs and polymorphisms in JAK3 gene have been associated with CV events in incident dialysis patients. Therefore, the aim of this study was to assess the potential role of JAK3 polymorphisms in the development of CV disease in patients with RA. 2136 Spanish RA patients were genotyped for the rs3212780 and rs3212752 JAK3 gene polymorphisms by TaqMan assays. Subclinical atherosclerosis was evaluated in 539 of these patients by carotid ultrasonography (US). No statistically significant differences were found when each polymorphism was assessed according to carotid intima-media thickness values and presence/absence of carotid plaques in RA, after adjusting the results for potential confounders. Moreover, no significant differences were obtained when RA patients were stratified according to the presence/absence of CV events after adjusting for potential confounders. In conclusion, our results do not confirm association between JAK3 polymorphisms and CV disease in RA.http://dx.doi.org/10.1155/2015/318364 |