TNF-α -308G/A polymorphism and susceptibility to tuberculosis in Azeri population of Iran

• Main Authors: Ghorghanlu Sajjad, Asgharzadeh Mohammad, Samadi-Kafil Hossein, Khaki-Khatibi Fatemeh, Rashedi Jalil, Mahdavi Poor Behroz, Moaddab Seyyed Reza, Pourostadi Mahya
• Format: Article
• Language: English
• Published: Serbian Genetics Society 2016-01-01
• Series: Genetika
• Subjects: association; single nucleotide polymorphism; tuberculosis; tumor necrosis factor-α; susceptibility
• Online Access: http://www.doiserbia.nb.rs/img/doi/0534-0012/2016/0534-00121603819G.pdf

Single nucleotide polymorphisms (SNPs) in cytokine genes may alter the level and function of secreted cytokine; therefore, SNPs can influence the immune response. The aim of the present study was to determine the association of TNF-α -308G/A single nucleotide polymorphism in tuberculosis patients in the Azeri population of Iran. The TNF-308G/A single nucleotide polymorphism in the promoter region was genotyped by using the allele-specific PCR method in 200 healthy controls and 124 tuberculosis patients. The distribution of allele frequencies for TNF-α -308G/A polymorphism between control and tuberculosis patient groups was not significant (P-value = 0.058, OR = 1.5). Furthermore, no statistically significant association was found between TNF-α -308G/A genotype and resistance/susceptibility to TB (P-value = 0.102). Our results suggest that TNF-α -308G/A polymorphism has no measurable effect on the development of tuberculosis in Azeri population of Iran.