A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats.
A fatty acid analogue, 2-(tridec-12-yn-1-ylthio)acetic acid (1-triple TTA), was previously shown to have hypolipidemic effects in rats by targeting mitochondrial activity predominantly in liver. This study aimed to determine if 1-triple TTA could influence carbohydrate metabolism. Male Wistar rats w...
Main Authors: | Carine Lindquist, Bodil Bjørndal, Hege G Bakke, Grete Slettom, Marie Karoliussen, Arild C Rustan, G Hege Thoresen, Jon Skorve, Ottar K Nygård, Rolf Kristian Berge |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019-01-01
|
Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0222558 |
Similar Items
-
Remodeling of oxidative energy metabolism by galactose improves glucose handling and metabolic switching in human skeletal muscle cells.
by: Eili Tranheim Kase, et al.
Published: (2013-01-01) -
A Phospholipid-Protein Complex from Antarctic Krill Reduced Plasma Homocysteine Levels and Increased Plasma Trimethylamine-N-Oxide (TMAO) and Carnitine Levels in Male Wistar Rats
by: Bodil Bjørndal, et al.
Published: (2015-09-01) -
Simvastatin inhibits glucose metabolism and legumain activity in human myotubes.
by: Robert Smith, et al.
Published: (2014-01-01) -
Eicosapentaenoic acid (20:5 n-3) increases fatty acid and glucose uptake in cultured human skeletal muscle cells
by: Vigdis Aas, et al.
Published: (2006-02-01) -
A fatty acid analogue targeting mitochondria exerts a plasma triacylglycerol lowering effect in rats with impaired carnitine biosynthesis.
by: Carine Lindquist, et al.
Published: (2018-01-01)