The Cardioprotective Signaling Activity of Activated Protein C in Heart Failure and Ischemic Heart Diseases
Activated protein C (APC) is a vitamin-K dependent plasma serine protease, which functions as a natural anticoagulant to downregulate thrombin generation in the clotting cascade. APC also modulates cellular homeostasis by exhibiting potent cytoprotective and anti-inflammatory signaling activities. T...
Main Authors: | Di Ren, Hemant Giri, Ji Li, Alireza R. Rezaie |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-04-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/20/7/1762 |
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