STIM1/ORAI1 Loss-of-Function and Gain-of-Function Mutations Inversely Impact on SOCE and Calcium Homeostasis and Cause Multi-Systemic Mirror Diseases

STIM1/ORAI1 Loss-of-Function and Gain-of-Function Mutations Inversely Impact on SOCE and Calcium Homeostasis and Cause Multi-Systemic Mirror Diseases

Store-operated Ca2+ entry (SOCE) is a ubiquitous and essential mechanism regulating Ca2+ homeostasis in all tissues, and controls a wide range of cellular functions including keratinocyte differentiation, osteoblastogenesis and osteoclastogenesis, T cell proliferation, platelet activation, and muscl...

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Bibliographic Details
Main Authors: Roberto Silva-Rojas, Jocelyn Laporte, Johann Böhm
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Physiology
Subjects:
SOCE
calcium
STIM1
ORAI1
CRAC channelopathy
tubular aggregate myopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.604941/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.604941/full

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