De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands

Aberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours. Here the authors use ectopically integrated CpG islands in colorectal cancer cells and find that aberrantly methylated CpG islands are subject to low levels of de novo DNA methylation, and that instead de n...

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Main Authors:	Roza H. Ali Masalmeh, Francesca Taglini, Cristina Rubio-Ramon, Kamila I. Musialik, Jonathan Higham, Hazel Davidson-Smith, Ioannis Kafetzopoulos, Kamila P. Pawlicka, Hannah M. Finan, Richard Clark, Jimi Wills, Andrew J. Finch, Lee Murphy, Duncan Sproul
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-20716-w

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spelling	doaj-9803ec9958634a5e94312be4787e0b292021-01-31T12:20:20ZengNature Publishing GroupNature Communications2041-17232021-01-0112111310.1038/s41467-020-20716-wDe novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islandsRoza H. Ali Masalmeh0Francesca Taglini1Cristina Rubio-Ramon2Kamila I. Musialik3Jonathan Higham4Hazel Davidson-Smith5Ioannis Kafetzopoulos6Kamila P. Pawlicka7Hannah M. Finan8Richard Clark9Jimi Wills10Andrew J. Finch11Lee Murphy12Duncan Sproul13MRC Human Genetics Unit, IGMM, University of EdinburghMRC Human Genetics Unit, IGMM, University of EdinburghMRC Human Genetics Unit, IGMM, University of EdinburghMRC Human Genetics Unit, IGMM, University of EdinburghMRC Human Genetics Unit, IGMM, University of EdinburghMRC Human Genetics Unit, IGMM, University of EdinburghMRC Human Genetics Unit, IGMM, University of EdinburghMRC Human Genetics Unit, IGMM, University of EdinburghMRC Human Genetics Unit, IGMM, University of EdinburghEdinburgh Clinical Research Facility, University of EdinburghCRUK Edinburgh Centre, IGMM, University of EdinburghCRUK Edinburgh Centre, IGMM, University of EdinburghEdinburgh Clinical Research Facility, University of EdinburghMRC Human Genetics Unit, IGMM, University of EdinburghAberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours. Here the authors use ectopically integrated CpG islands in colorectal cancer cells and find that aberrantly methylated CpG islands are subject to low levels of de novo DNA methylation, and that instead de novo DNA methylation activity is targeted primarily to CpG islands marked by the histone modification H3K36me3.https://doi.org/10.1038/s41467-020-20716-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Roza H. Ali Masalmeh Francesca Taglini Cristina Rubio-Ramon Kamila I. Musialik Jonathan Higham Hazel Davidson-Smith Ioannis Kafetzopoulos Kamila P. Pawlicka Hannah M. Finan Richard Clark Jimi Wills Andrew J. Finch Lee Murphy Duncan Sproul
spellingShingle	Roza H. Ali Masalmeh Francesca Taglini Cristina Rubio-Ramon Kamila I. Musialik Jonathan Higham Hazel Davidson-Smith Ioannis Kafetzopoulos Kamila P. Pawlicka Hannah M. Finan Richard Clark Jimi Wills Andrew J. Finch Lee Murphy Duncan Sproul De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands Nature Communications
author_facet	Roza H. Ali Masalmeh Francesca Taglini Cristina Rubio-Ramon Kamila I. Musialik Jonathan Higham Hazel Davidson-Smith Ioannis Kafetzopoulos Kamila P. Pawlicka Hannah M. Finan Richard Clark Jimi Wills Andrew J. Finch Lee Murphy Duncan Sproul
author_sort	Roza H. Ali Masalmeh
title	De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands
title_short	De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands
title_full	De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands
title_fullStr	De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands
title_full_unstemmed	De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands
title_sort	de novo dna methyltransferase activity in colorectal cancer is directed towards h3k36me3 marked cpg islands
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-01-01
description	Aberrant gain of DNA methylation at CpG islands is frequently observed in colorectal tumours. Here the authors use ectopically integrated CpG islands in colorectal cancer cells and find that aberrantly methylated CpG islands are subject to low levels of de novo DNA methylation, and that instead de novo DNA methylation activity is targeted primarily to CpG islands marked by the histone modification H3K36me3.
url	https://doi.org/10.1038/s41467-020-20716-w
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De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands

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