Clinicopathological characteristics of -associated breast cancer in Asian patients
BRCA1/2 germline mutations account for the majority of hereditary breast cancers. Since the identification of the BRCA genes, several attempts have been made to define the clinicopathological characteristics of BRCA-associated breast cancer in comparison with sporadic breast cancer. Asians constitut...
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Korean Society of Pathologists & the Korean Society for Cytopathology
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doaj-980838a308594141aa144745c4e7c4512020-11-25T03:05:51ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452020-07-0154426527510.4132/jptm.2020.04.0716909Clinicopathological characteristics of -associated breast cancer in Asian patientsEun-Kyu Kim0So Yeon Park1Sung-Won Kim2 Department of Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Surgery, Daerim St. Mary’s Hospital, Seoul, KoreaBRCA1/2 germline mutations account for the majority of hereditary breast cancers. Since the identification of the BRCA genes, several attempts have been made to define the clinicopathological characteristics of BRCA-associated breast cancer in comparison with sporadic breast cancer. Asians constitute 60% of the world population, and although the incidence of breast cancer in Asia remains low compared to the West, breast cancer is the most prevalent female cancer in the region. The epidemiological aspects of breast cancer are different between Asians and Caucasians. Asian patients present with breast cancer at a younger age than Western patients. The contributions of BRCA1/2 mutations to breast cancer incidence are expected to differ between Asians and Caucasians, and the different genetic backgrounds among races are likely to influence the breast cancer phenotypes. However, most large-scale studies on the clinicopathological characteristics of BRCA-associated breast cancer have been on Western patients, while studies on Asian populations were small and sporadic. In this review, we provide an overview of the clinical and pathological characteristics of BRCA-associated breast cancer, incorporating findings on Asian patients.http://www.jpatholtm.org/upload/pdf/jptm-2020-04-07.pdfbreast neoplasmsgenes, brca1genes, brca2asian continental ancestry group |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eun-Kyu Kim So Yeon Park Sung-Won Kim |
spellingShingle |
Eun-Kyu Kim So Yeon Park Sung-Won Kim Clinicopathological characteristics of -associated breast cancer in Asian patients Journal of Pathology and Translational Medicine breast neoplasms genes, brca1 genes, brca2 asian continental ancestry group |
author_facet |
Eun-Kyu Kim So Yeon Park Sung-Won Kim |
author_sort |
Eun-Kyu Kim |
title |
Clinicopathological characteristics of -associated breast cancer in Asian patients |
title_short |
Clinicopathological characteristics of -associated breast cancer in Asian patients |
title_full |
Clinicopathological characteristics of -associated breast cancer in Asian patients |
title_fullStr |
Clinicopathological characteristics of -associated breast cancer in Asian patients |
title_full_unstemmed |
Clinicopathological characteristics of -associated breast cancer in Asian patients |
title_sort |
clinicopathological characteristics of -associated breast cancer in asian patients |
publisher |
Korean Society of Pathologists & the Korean Society for Cytopathology |
series |
Journal of Pathology and Translational Medicine |
issn |
2383-7837 2383-7845 |
publishDate |
2020-07-01 |
description |
BRCA1/2 germline mutations account for the majority of hereditary breast cancers. Since the identification of the BRCA genes, several attempts have been made to define the clinicopathological characteristics of BRCA-associated breast cancer in comparison with sporadic breast cancer. Asians constitute 60% of the world population, and although the incidence of breast cancer in Asia remains low compared to the West, breast cancer is the most prevalent female cancer in the region. The epidemiological aspects of breast cancer are different between Asians and Caucasians. Asian patients present with breast cancer at a younger age than Western patients. The contributions of BRCA1/2 mutations to breast cancer incidence are expected to differ between Asians and Caucasians, and the different genetic backgrounds among races are likely to influence the breast cancer phenotypes. However, most large-scale studies on the clinicopathological characteristics of BRCA-associated breast cancer have been on Western patients, while studies on Asian populations were small and sporadic. In this review, we provide an overview of the clinical and pathological characteristics of BRCA-associated breast cancer, incorporating findings on Asian patients. |
topic |
breast neoplasms genes, brca1 genes, brca2 asian continental ancestry group |
url |
http://www.jpatholtm.org/upload/pdf/jptm-2020-04-07.pdf |
work_keys_str_mv |
AT eunkyukim clinicopathologicalcharacteristicsofassociatedbreastcancerinasianpatients AT soyeonpark clinicopathologicalcharacteristicsofassociatedbreastcancerinasianpatients AT sungwonkim clinicopathologicalcharacteristicsofassociatedbreastcancerinasianpatients |
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1724676880656760832 |