Mast cells as novel mediators of reproductive processes
The relationship between mast cells (MCs) and pregnancy is a controversially discussed topic. The presence and quantitative distribution of mast cells in the reproductive tract was confirmed in different species. A phase-dependent oscillation of mast cells during the hormonal regulated oestrous cycl...
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2013-02-01
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doaj-9815a9ada1254dff8a6b796543f87eb92020-11-24T23:13:41ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-02-01410.3389/fimmu.2013.0002925424Mast cells as novel mediators of reproductive processesKatja eWoidacki0Federico eJensen1Ana Claudia Zenclussen2Medical Faculty, Otto-von-Guericke UniversityMedical Faculty, Otto-von-Guericke UniversityMedical Faculty, Otto-von-Guericke UniversityThe relationship between mast cells (MCs) and pregnancy is a controversially discussed topic. The presence and quantitative distribution of mast cells in the reproductive tract was confirmed in different species. A phase-dependent oscillation of mast cells during the hormonal regulated oestrous cycle was suggested and on this basis, MCs were assumed to play a positive role in implantation because of their ability to secrete histamine. At later pregnancy stages, they were proposed to have rather a negative role, as their exacerbated activation is associated with pre-term delivery. The present review is intended to provide an overview about uterine MCs that bring to light their unexpected relevance for reproductive processes.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00029/fullMast CellsPlacentaPregnancyUterusimplantation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Katja eWoidacki Federico eJensen Ana Claudia Zenclussen |
spellingShingle |
Katja eWoidacki Federico eJensen Ana Claudia Zenclussen Mast cells as novel mediators of reproductive processes Frontiers in Immunology Mast Cells Placenta Pregnancy Uterus implantation |
author_facet |
Katja eWoidacki Federico eJensen Ana Claudia Zenclussen |
author_sort |
Katja eWoidacki |
title |
Mast cells as novel mediators of reproductive processes |
title_short |
Mast cells as novel mediators of reproductive processes |
title_full |
Mast cells as novel mediators of reproductive processes |
title_fullStr |
Mast cells as novel mediators of reproductive processes |
title_full_unstemmed |
Mast cells as novel mediators of reproductive processes |
title_sort |
mast cells as novel mediators of reproductive processes |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2013-02-01 |
description |
The relationship between mast cells (MCs) and pregnancy is a controversially discussed topic. The presence and quantitative distribution of mast cells in the reproductive tract was confirmed in different species. A phase-dependent oscillation of mast cells during the hormonal regulated oestrous cycle was suggested and on this basis, MCs were assumed to play a positive role in implantation because of their ability to secrete histamine. At later pregnancy stages, they were proposed to have rather a negative role, as their exacerbated activation is associated with pre-term delivery. The present review is intended to provide an overview about uterine MCs that bring to light their unexpected relevance for reproductive processes. |
topic |
Mast Cells Placenta Pregnancy Uterus implantation |
url |
http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00029/full |
work_keys_str_mv |
AT katjaewoidacki mastcellsasnovelmediatorsofreproductiveprocesses AT federicoejensen mastcellsasnovelmediatorsofreproductiveprocesses AT anaclaudiazenclussen mastcellsasnovelmediatorsofreproductiveprocesses |
_version_ |
1725597185116995584 |