Different Plaque Composition and Progression in Patients with Stable and Unstable Coronary Syndromes Evaluated by Cardiac CT
Objective. To compare the quantity, subtype, and progression of atherosclerosis by cardiac computed tomography (CT) and intravascular ultrasound (IVUS) in patients with stable (SAP) and unstable angina pectoris or non-ST-elevation myocardial infarction (UAP/n-STEMI). Methods. Forty patients with SAP...
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Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2015/401357 |
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doaj-9815c42797d24f9e8c182c7d543a69922020-11-24T23:55:22ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/401357401357Different Plaque Composition and Progression in Patients with Stable and Unstable Coronary Syndromes Evaluated by Cardiac CTMaiken Glud Dalager0Morten Bøttcher1Jesper Thygesen2Gratien Andersen3Hans Erik Bøtker4Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, DenmarkCardiac Imaging Center, Hospital Unit Vest, Gl. Landevej 61, 7400 Herning, DenmarkDepartment of Biomedical Engineering, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, DenmarkDepartment of Radiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, DenmarkDepartment of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, DenmarkObjective. To compare the quantity, subtype, and progression of atherosclerosis by cardiac computed tomography (CT) and intravascular ultrasound (IVUS) in patients with stable (SAP) and unstable angina pectoris or non-ST-elevation myocardial infarction (UAP/n-STEMI). Methods. Forty patients with SAP and 20 with UAP/n-STEMI underwent cardiac CT and angiography with IVUS at baseline and after one year. Atherosclerotic segments were divided into calcified, mixed, or noncalcified subtypes, and significant stenoses were registered. Results. Thirty-two SAP and 15 UAP/n-STEMI patients completed the CT follow-up. At baseline, the number of atherosclerotic segments was higher in UAP/n-STEMI than in SAP (P=0.039). UAP/n-STEMI patients had more segments with noncalcified plaques (P=0.0005) whereas SAP patients had more segments with calcified plaques (P=0.013). The number of segments with significant stenosis did not differ between the groups, but noncalcified plaques more frequently caused significant stenoses in UAP/n-STEMI than in SAP patients (P=0.0002). After one year the number of segments with atherosclerosis increased in SAP patients (P=0.0001). The number of atherosclerotic segments remained unchanged in UAP/n-STEMI patients. However, composition was altered as the number of segments with noncalcified plaques decreased (P=0.018). IVUS data confirmed the CT findings. Conclusion. Quantity, subtype, and progression of atherosclerosis differ between SAP and UAP/n-STEMI patients.http://dx.doi.org/10.1155/2015/401357 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maiken Glud Dalager Morten Bøttcher Jesper Thygesen Gratien Andersen Hans Erik Bøtker |
spellingShingle |
Maiken Glud Dalager Morten Bøttcher Jesper Thygesen Gratien Andersen Hans Erik Bøtker Different Plaque Composition and Progression in Patients with Stable and Unstable Coronary Syndromes Evaluated by Cardiac CT BioMed Research International |
author_facet |
Maiken Glud Dalager Morten Bøttcher Jesper Thygesen Gratien Andersen Hans Erik Bøtker |
author_sort |
Maiken Glud Dalager |
title |
Different Plaque Composition and Progression in Patients with Stable and Unstable Coronary Syndromes Evaluated by Cardiac CT |
title_short |
Different Plaque Composition and Progression in Patients with Stable and Unstable Coronary Syndromes Evaluated by Cardiac CT |
title_full |
Different Plaque Composition and Progression in Patients with Stable and Unstable Coronary Syndromes Evaluated by Cardiac CT |
title_fullStr |
Different Plaque Composition and Progression in Patients with Stable and Unstable Coronary Syndromes Evaluated by Cardiac CT |
title_full_unstemmed |
Different Plaque Composition and Progression in Patients with Stable and Unstable Coronary Syndromes Evaluated by Cardiac CT |
title_sort |
different plaque composition and progression in patients with stable and unstable coronary syndromes evaluated by cardiac ct |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Objective. To compare the quantity, subtype, and progression of atherosclerosis by cardiac computed tomography (CT) and intravascular ultrasound (IVUS) in patients with stable (SAP) and unstable angina pectoris or non-ST-elevation myocardial infarction (UAP/n-STEMI). Methods. Forty patients with SAP and 20 with UAP/n-STEMI underwent cardiac CT and angiography with IVUS at baseline and after one year. Atherosclerotic segments were divided into calcified, mixed, or noncalcified subtypes, and significant stenoses were registered. Results. Thirty-two SAP and 15 UAP/n-STEMI patients completed the CT follow-up. At baseline, the number of atherosclerotic segments was higher in UAP/n-STEMI than in SAP (P=0.039). UAP/n-STEMI patients had more segments with noncalcified plaques (P=0.0005) whereas SAP patients had more segments with calcified plaques (P=0.013). The number of segments with significant stenosis did not differ between the groups, but noncalcified plaques more frequently caused significant stenoses in UAP/n-STEMI than in SAP patients (P=0.0002). After one year the number of segments with atherosclerosis increased in SAP patients (P=0.0001). The number of atherosclerotic segments remained unchanged in UAP/n-STEMI patients. However, composition was altered as the number of segments with noncalcified plaques decreased (P=0.018). IVUS data confirmed the CT findings. Conclusion. Quantity, subtype, and progression of atherosclerosis differ between SAP and UAP/n-STEMI patients. |
url |
http://dx.doi.org/10.1155/2015/401357 |
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