Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae
Teichoic acid is bound to peptidoglycan (wall teichoic acid, WTA) or to membrane glycolipids (lipoteichoic acid, LTA) in most Gram-positive bacteria. Here, the authors identify a putative ligase required for the assembly of LTA, but not WTA, and important for Streptococcus pneumoniae virulence in mo...
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2017-12-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-01720-z |
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doaj-981ad421dad041efb626412019f1aa322021-05-11T07:53:17ZengNature Publishing GroupNature Communications2041-17232017-12-018111310.1038/s41467-017-01720-zLipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniaeNathalie Heß0Franziska Waldow1Thomas P. Kohler2Manfred Rohde3Bernd Kreikemeyer4Alejandro Gómez-Mejia5Torsten Hain6Dominik Schwudke7Waldemar Vollmer8Sven Hammerschmidt9Nicolas Gisch10Department of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, University of GreifswaldDivision of Bioanalytical Chemistry, Priority Area Infections, Research Center Borstel, Leibniz-Center for Medicine and BiosciencesDepartment of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, University of GreifswaldCentral Facility for Microscopy, HZI - Helmholtz Centre for Infection ResearchUniversity Medicine, Institute of Medical Microbiology, Virology and Hygiene, Rostock UniversityDepartment of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, University of GreifswaldInstitute for Medical Microbiology, Justus-Liebig University of GiessenDivision of Bioanalytical Chemistry, Priority Area Infections, Research Center Borstel, Leibniz-Center for Medicine and BiosciencesCentre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle UniversityDepartment of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, University of GreifswaldDivision of Bioanalytical Chemistry, Priority Area Infections, Research Center Borstel, Leibniz-Center for Medicine and BiosciencesTeichoic acid is bound to peptidoglycan (wall teichoic acid, WTA) or to membrane glycolipids (lipoteichoic acid, LTA) in most Gram-positive bacteria. Here, the authors identify a putative ligase required for the assembly of LTA, but not WTA, and important for Streptococcus pneumoniae virulence in mouse models.https://doi.org/10.1038/s41467-017-01720-z |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nathalie Heß Franziska Waldow Thomas P. Kohler Manfred Rohde Bernd Kreikemeyer Alejandro Gómez-Mejia Torsten Hain Dominik Schwudke Waldemar Vollmer Sven Hammerschmidt Nicolas Gisch |
spellingShingle |
Nathalie Heß Franziska Waldow Thomas P. Kohler Manfred Rohde Bernd Kreikemeyer Alejandro Gómez-Mejia Torsten Hain Dominik Schwudke Waldemar Vollmer Sven Hammerschmidt Nicolas Gisch Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae Nature Communications |
author_facet |
Nathalie Heß Franziska Waldow Thomas P. Kohler Manfred Rohde Bernd Kreikemeyer Alejandro Gómez-Mejia Torsten Hain Dominik Schwudke Waldemar Vollmer Sven Hammerschmidt Nicolas Gisch |
author_sort |
Nathalie Heß |
title |
Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae |
title_short |
Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae |
title_full |
Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae |
title_fullStr |
Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae |
title_full_unstemmed |
Lipoteichoic acid deficiency permits normal growth but impairs virulence of Streptococcus pneumoniae |
title_sort |
lipoteichoic acid deficiency permits normal growth but impairs virulence of streptococcus pneumoniae |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-12-01 |
description |
Teichoic acid is bound to peptidoglycan (wall teichoic acid, WTA) or to membrane glycolipids (lipoteichoic acid, LTA) in most Gram-positive bacteria. Here, the authors identify a putative ligase required for the assembly of LTA, but not WTA, and important for Streptococcus pneumoniae virulence in mouse models. |
url |
https://doi.org/10.1038/s41467-017-01720-z |
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