Determination of administered activities for the treatment of Graves' disease with iodine-131: Proposition of a simplified dosimetric procedure
This prospective study included 35 patients suffering from Graves' disease (GD) clinically and biologically confirmed by endocrinologists, sent to the nuclear medicine department of CHU de Bab El Oued, Algiers for iodine-131 therapy. CHU de Bab El Oued is a tertiary hospital located in the cent...
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2021-01-01
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doaj-982890e529a341f1977120eca62818de2021-10-07T06:58:15ZengWolters Kluwer Medknow PublicationsWorld Journal of Nuclear Medicine1450-11471607-33122021-01-0120322222710.4103/wjnm.WJNM_47_20Determination of administered activities for the treatment of Graves' disease with iodine-131: Proposition of a simplified dosimetric procedureIdrissa Adamou SoliDjibrillou Moussa IssoufouSkander RahabiAda AliEric AdehossiSalah Eddine BouyoucefThis prospective study included 35 patients suffering from Graves' disease (GD) clinically and biologically confirmed by endocrinologists, sent to the nuclear medicine department of CHU de Bab El Oued, Algiers for iodine-131 therapy. CHU de Bab El Oued is a tertiary hospital located in the center of the capital Algiers. The aim of this study is to propose a simplified dosimetric procedure which will initiate iodine-131 therapy of GD in particular and hyperthyroidism in general in Niger. The determination of the maximum uptake was performed with a Biodex external probe at 2 h, 4 h, and 24 h after the administration of 3 MBq of liquid iodine-131. The iodine-131 activities were determined using the Marinelli formula with a predefined effective half-life (Te) of 5 days and subsequently extrapolated half-life with kaleidagraph software. The statistical analysis was performed using an excel sheet and analyzed using the software package Statistica 10 (stat Soft, Tulsa, USA). the male:female gender ratio was1:4.5 and the mean age was 42.56 years (±7.14). The body mass index was within normal range with a value of 25.25 kg2 (±0.42) and the mean average thyroid mass was equal to 24.05 (±10.53) g. The mean uptake value at 24 h was 43.24% (±17.68%) meanwhile the maximum uptake value was 46.28 (±21.13%). The estimated effective half-life (Te) was 5.44 days (±1.96) days which were different from the predefined Te of 5 days. The mean activity determined with fixed Te and 24 h uptake was 244.45 (±109.2) MBq and the mean activity calculated with both extrapolated Te and maximum uptake was 452.22 (±381.9) MBq. Empirical determination of activity in the treatment of GD gives higher activities (1.5 times) to patients than dosimetric methods based on the determination of extrapolated effective half-life.http://www.wjnm.org/article.asp?issn=1450-1147;year=2021;volume=20;issue=3;spage=222;epage=227;aulast=dosimetryempiric activitiesextrapolated effective half-lifeoptimizationplanningpredefined effective half-lifeuptake |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Idrissa Adamou Soli Djibrillou Moussa Issoufou Skander Rahabi Ada Ali Eric Adehossi Salah Eddine Bouyoucef |
spellingShingle |
Idrissa Adamou Soli Djibrillou Moussa Issoufou Skander Rahabi Ada Ali Eric Adehossi Salah Eddine Bouyoucef Determination of administered activities for the treatment of Graves' disease with iodine-131: Proposition of a simplified dosimetric procedure World Journal of Nuclear Medicine dosimetry empiric activities extrapolated effective half-life optimization planning predefined effective half-life uptake |
author_facet |
Idrissa Adamou Soli Djibrillou Moussa Issoufou Skander Rahabi Ada Ali Eric Adehossi Salah Eddine Bouyoucef |
author_sort |
Idrissa Adamou Soli |
title |
Determination of administered activities for the treatment of Graves' disease with iodine-131: Proposition of a simplified dosimetric procedure |
title_short |
Determination of administered activities for the treatment of Graves' disease with iodine-131: Proposition of a simplified dosimetric procedure |
title_full |
Determination of administered activities for the treatment of Graves' disease with iodine-131: Proposition of a simplified dosimetric procedure |
title_fullStr |
Determination of administered activities for the treatment of Graves' disease with iodine-131: Proposition of a simplified dosimetric procedure |
title_full_unstemmed |
Determination of administered activities for the treatment of Graves' disease with iodine-131: Proposition of a simplified dosimetric procedure |
title_sort |
determination of administered activities for the treatment of graves' disease with iodine-131: proposition of a simplified dosimetric procedure |
publisher |
Wolters Kluwer Medknow Publications |
series |
World Journal of Nuclear Medicine |
issn |
1450-1147 1607-3312 |
publishDate |
2021-01-01 |
description |
This prospective study included 35 patients suffering from Graves' disease (GD) clinically and biologically confirmed by endocrinologists, sent to the nuclear medicine department of CHU de Bab El Oued, Algiers for iodine-131 therapy. CHU de Bab El Oued is a tertiary hospital located in the center of the capital Algiers. The aim of this study is to propose a simplified dosimetric procedure which will initiate iodine-131 therapy of GD in particular and hyperthyroidism in general in Niger. The determination of the maximum uptake was performed with a Biodex external probe at 2 h, 4 h, and 24 h after the administration of 3 MBq of liquid iodine-131. The iodine-131 activities were determined using the Marinelli formula with a predefined effective half-life (Te) of 5 days and subsequently extrapolated half-life with kaleidagraph software. The statistical analysis was performed using an excel sheet and analyzed using the software package Statistica 10 (stat Soft, Tulsa, USA). the male:female gender ratio was1:4.5 and the mean age was 42.56 years (±7.14). The body mass index was within normal range with a value of 25.25 kg2 (±0.42) and the mean average thyroid mass was equal to 24.05 (±10.53) g. The mean uptake value at 24 h was 43.24% (±17.68%) meanwhile the maximum uptake value was 46.28 (±21.13%). The estimated effective half-life (Te) was 5.44 days (±1.96) days which were different from the predefined Te of 5 days. The mean activity determined with fixed Te and 24 h uptake was 244.45 (±109.2) MBq and the mean activity calculated with both extrapolated Te and maximum uptake was 452.22 (±381.9) MBq. Empirical determination of activity in the treatment of GD gives higher activities (1.5 times) to patients than dosimetric methods based on the determination of extrapolated effective half-life. |
topic |
dosimetry empiric activities extrapolated effective half-life optimization planning predefined effective half-life uptake |
url |
http://www.wjnm.org/article.asp?issn=1450-1147;year=2021;volume=20;issue=3;spage=222;epage=227;aulast= |
work_keys_str_mv |
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