Immunoglobulin free light chains and GAGs mediate Multiple Myeloma Extracellular Vesicles uptake and secondary NfkB nuclear translocation
Multiple Myeloma (MM) is a hematological malignancy caused by a microenviromentally-aided persistence of plasma cells in the bone marrow. Monoclonal plasma cells often secrete high amounts of immunoglobulin free light chains (FLCs) that could induce tissue damage. Recently we showed that FLCs are in...
Main Authors: | Giuseppe eDi Noto, Marco eChiarini, Lucia ePaolini, Elena eMazzoldi, Viviana eGiustini, Annalisa eRadeghieri, Luigi eCaimi, Doris eRicotta |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2014-10-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00517/full |
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