Migrasome and Tetraspanins in Vascular Homeostasis: Concept, Present, and Future
Cell migration plays a critical role in vascular homeostasis. Under noxious stimuli, endothelial cells (ECs) migration always contributes to vascular repair, while enhanced migration of vascular smooth muscle cells (VSMCs) will lead to pathological vascular remodeling. Moreover, vascular activities...
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doaj-982ed3ddd977433cb2066c10b6972faa2020-11-25T03:26:59ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-06-01810.3389/fcell.2020.00438543235Migrasome and Tetraspanins in Vascular Homeostasis: Concept, Present, and FutureYaxing Zhang0Jing Wang1Yungang Ding2Jiongshan Zhang3Yan Xu4Jingting Xu5Shuhui Zheng6Hongzhi Yang7Department of Traditional Chinese Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Ophthalmology, Qingdao Fubai Eye Hospital, Qingdao, ChinaDepartment of Ophthalmology, Qingdao Ludong Eye Hospital, Qingdao, ChinaDepartment of Traditional Chinese Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Gastrointestinal Endoscopy, Guangzhou Cadre Health Management Center/Guangzhou Eleventh People’s Hospital, Guangzhou, ChinaBiofeedback Laboratory, Xinhua College of Sun Yat-sen University, Guangzhou, ChinaResearch Center for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaDepartment of Traditional Chinese Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, ChinaCell migration plays a critical role in vascular homeostasis. Under noxious stimuli, endothelial cells (ECs) migration always contributes to vascular repair, while enhanced migration of vascular smooth muscle cells (VSMCs) will lead to pathological vascular remodeling. Moreover, vascular activities are involved in communication between ECs and VSMCs, between ECs and immune cells, et al. Recently, Ma et al. (2015) discovered a novel migration-dependent organelle “migrasome,” which mediated release of cytoplasmic contents, and this process was defined as “migracytosis.” The formation of migrasome is precisely regulated by tetraspanins (TSPANs), cholesterol and integrins. Migrasomes can be taken up by neighboring cells, and migrasomes are distributed in many kinds of cells and tissues, such as in blood vessel, human serum, and in ischemic brain of human and mouse. In addition, the migrasome elements TSPANs are wildly expressed in cardiovascular system. Therefore, TSPANs, migrasomes and migracytosis might play essential roles in regulating vascular homeostasis. In this review, we will discuss the discoveries of migration-dependent migrasome and migracytosis, migrasome formation, the basic differences between migrasomes and exosomes, the distributions and functions of migrasome, the functions of migrasome elements TSPANs in vascular biology, and discuss the possible roles of migrasomes and migracytosis in vascular homeostasis.https://www.frontiersin.org/article/10.3389/fcell.2020.00438/fullcell migrationmigrasomemigracytosistetraspaninsvascular homeostasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yaxing Zhang Jing Wang Yungang Ding Jiongshan Zhang Yan Xu Jingting Xu Shuhui Zheng Hongzhi Yang |
spellingShingle |
Yaxing Zhang Jing Wang Yungang Ding Jiongshan Zhang Yan Xu Jingting Xu Shuhui Zheng Hongzhi Yang Migrasome and Tetraspanins in Vascular Homeostasis: Concept, Present, and Future Frontiers in Cell and Developmental Biology cell migration migrasome migracytosis tetraspanins vascular homeostasis |
author_facet |
Yaxing Zhang Jing Wang Yungang Ding Jiongshan Zhang Yan Xu Jingting Xu Shuhui Zheng Hongzhi Yang |
author_sort |
Yaxing Zhang |
title |
Migrasome and Tetraspanins in Vascular Homeostasis: Concept, Present, and Future |
title_short |
Migrasome and Tetraspanins in Vascular Homeostasis: Concept, Present, and Future |
title_full |
Migrasome and Tetraspanins in Vascular Homeostasis: Concept, Present, and Future |
title_fullStr |
Migrasome and Tetraspanins in Vascular Homeostasis: Concept, Present, and Future |
title_full_unstemmed |
Migrasome and Tetraspanins in Vascular Homeostasis: Concept, Present, and Future |
title_sort |
migrasome and tetraspanins in vascular homeostasis: concept, present, and future |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2020-06-01 |
description |
Cell migration plays a critical role in vascular homeostasis. Under noxious stimuli, endothelial cells (ECs) migration always contributes to vascular repair, while enhanced migration of vascular smooth muscle cells (VSMCs) will lead to pathological vascular remodeling. Moreover, vascular activities are involved in communication between ECs and VSMCs, between ECs and immune cells, et al. Recently, Ma et al. (2015) discovered a novel migration-dependent organelle “migrasome,” which mediated release of cytoplasmic contents, and this process was defined as “migracytosis.” The formation of migrasome is precisely regulated by tetraspanins (TSPANs), cholesterol and integrins. Migrasomes can be taken up by neighboring cells, and migrasomes are distributed in many kinds of cells and tissues, such as in blood vessel, human serum, and in ischemic brain of human and mouse. In addition, the migrasome elements TSPANs are wildly expressed in cardiovascular system. Therefore, TSPANs, migrasomes and migracytosis might play essential roles in regulating vascular homeostasis. In this review, we will discuss the discoveries of migration-dependent migrasome and migracytosis, migrasome formation, the basic differences between migrasomes and exosomes, the distributions and functions of migrasome, the functions of migrasome elements TSPANs in vascular biology, and discuss the possible roles of migrasomes and migracytosis in vascular homeostasis. |
topic |
cell migration migrasome migracytosis tetraspanins vascular homeostasis |
url |
https://www.frontiersin.org/article/10.3389/fcell.2020.00438/full |
work_keys_str_mv |
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