Occurrence and Significance of the Nuclear Transcription Factor Krüppel-Like Factor 4 (KLF4) in the Vessel Wall

Occurrence and Significance of the Nuclear Transcription Factor Krüppel-Like Factor 4 (KLF4) in the Vessel Wall

Practically all mammalian cells including human can switch, according to micro- or macroenvironmental conditions, from states of cellular quiescence to inflammatory activation and vice versa. Along with recent knowledge, cellular quiescence is not a passive, but a highly active state with broad enga...

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Bibliographic Details
Main Authors: Pavel Kuneš, Zdeňka Holubcová, Jan Krejsek
Format: Article
Language:English
Published: Karolinum Press 2009-01-01
Series:Acta Medica
Subjects:
Endothelial phenotype
Inflammatory cytokines
Shear stress
Transcription factors
Arterial injury
Smooth muscle cells
Online Access:https://actamedica.lfhk.cuni.cz/52/4/0135/
Description
Summary:Practically all mammalian cells including human can switch, according to micro- or macroenvironmental conditions, from states of cellular quiescence to inflammatory activation and vice versa. Along with recent knowledge, cellular quiescence is not a passive, but a highly active state with broad engagement of the cell synthetic and secretory machinery. Inflammatory activation is a beneficial process in cases of infection; however, if its control fails, it may degrade into autoimmune diseases or cancer growth. Control over cellular quiescence is exerted predominantly by a set of zincfinger transcription proteins, referred to as Krüppel-like factors (KLFs). This review article offers recent information concerning activities of Krüppel-like factor 4 in the vascular wall.
ISSN:1211-4286
1805-9694

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