Polymorphisms at Myostatin Gene (<i>MSTN</i>) and the Associations with Sport Performances in Anglo-Arabian Racehorses
One hundred and eighty Anglo-Arabian horses running 1239 races were sampled for the present study. DNA was extracted from the blood and myostatin gene, <i>MSTN</i>, was genotyped. Moreover, prizes won and places were achieved for the 1239 races to perform association analyses between the...
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doaj-9836796710ce45e9b292d28916691e562021-03-30T23:06:38ZengMDPI AGAnimals2076-26152021-03-011196496410.3390/ani11040964Polymorphisms at Myostatin Gene (<i>MSTN</i>) and the Associations with Sport Performances in Anglo-Arabian RacehorsesEmanuela Pira0Giuseppe Massimo Vacca1Maria Luisa Dettori2Gianpiera Piras3Massimiliano Moro4Pietro Paschino5Michele Pazzola6Local Health Authority 7 Pedemontana, via dei Lotti 40, 36061 Bassano del Grappa, ItalyDepartment of Veterinary Medicine, University of Sassari, via Vienna 2, 07100 Sassari, ItalyDepartment of Veterinary Medicine, University of Sassari, via Vienna 2, 07100 Sassari, ItalyLocal Health Authority of Oristano, via Carducci 35, 09170 Oristano, ItalyLocal Health Authority of Nuoro, via Amerigo Demurtas 1, 08110 Nuoro, ItalyDepartment of Veterinary Medicine, University of Sassari, via Vienna 2, 07100 Sassari, ItalyDepartment of Veterinary Medicine, University of Sassari, via Vienna 2, 07100 Sassari, ItalyOne hundred and eighty Anglo-Arabian horses running 1239 races were sampled for the present study. DNA was extracted from the blood and myostatin gene, <i>MSTN</i>, was genotyped. Moreover, prizes won and places were achieved for the 1239 races to perform association analyses between the different genotypes and sport traits. Two SNPs already reported in previous studies regarding the Thoroughbred breed, rs69472472 and rs397152648, were revealed as polymorphic. The linkage disequilibrium analysis investigating the haplotype structure of <i>MSTN</i> did not evidence any association block. Polymorphism at SNP rs397152648, previously known as g.66493737 T>C, significantly influenced sport traits, with heterozygous horses TC showing better results than homozygotes TT. The portion of variance due to the random effect of the individual animal, and the other phenotypic effects of sex, percentage of Arabian blood and race distance, computed together with the genotype at <i>MSTN</i> in the statistical models, exerted a significant influence. Hence, this information is useful to improve knowledge of the genetic profile of Anglo-Arabian horses and a possible selection for better sport performance.https://www.mdpi.com/2076-2615/11/4/964myostatinracehorseAnglo-Arabian horse breednon-genetic effect |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Emanuela Pira Giuseppe Massimo Vacca Maria Luisa Dettori Gianpiera Piras Massimiliano Moro Pietro Paschino Michele Pazzola |
spellingShingle |
Emanuela Pira Giuseppe Massimo Vacca Maria Luisa Dettori Gianpiera Piras Massimiliano Moro Pietro Paschino Michele Pazzola Polymorphisms at Myostatin Gene (<i>MSTN</i>) and the Associations with Sport Performances in Anglo-Arabian Racehorses Animals myostatin racehorse Anglo-Arabian horse breed non-genetic effect |
author_facet |
Emanuela Pira Giuseppe Massimo Vacca Maria Luisa Dettori Gianpiera Piras Massimiliano Moro Pietro Paschino Michele Pazzola |
author_sort |
Emanuela Pira |
title |
Polymorphisms at Myostatin Gene (<i>MSTN</i>) and the Associations with Sport Performances in Anglo-Arabian Racehorses |
title_short |
Polymorphisms at Myostatin Gene (<i>MSTN</i>) and the Associations with Sport Performances in Anglo-Arabian Racehorses |
title_full |
Polymorphisms at Myostatin Gene (<i>MSTN</i>) and the Associations with Sport Performances in Anglo-Arabian Racehorses |
title_fullStr |
Polymorphisms at Myostatin Gene (<i>MSTN</i>) and the Associations with Sport Performances in Anglo-Arabian Racehorses |
title_full_unstemmed |
Polymorphisms at Myostatin Gene (<i>MSTN</i>) and the Associations with Sport Performances in Anglo-Arabian Racehorses |
title_sort |
polymorphisms at myostatin gene (<i>mstn</i>) and the associations with sport performances in anglo-arabian racehorses |
publisher |
MDPI AG |
series |
Animals |
issn |
2076-2615 |
publishDate |
2021-03-01 |
description |
One hundred and eighty Anglo-Arabian horses running 1239 races were sampled for the present study. DNA was extracted from the blood and myostatin gene, <i>MSTN</i>, was genotyped. Moreover, prizes won and places were achieved for the 1239 races to perform association analyses between the different genotypes and sport traits. Two SNPs already reported in previous studies regarding the Thoroughbred breed, rs69472472 and rs397152648, were revealed as polymorphic. The linkage disequilibrium analysis investigating the haplotype structure of <i>MSTN</i> did not evidence any association block. Polymorphism at SNP rs397152648, previously known as g.66493737 T>C, significantly influenced sport traits, with heterozygous horses TC showing better results than homozygotes TT. The portion of variance due to the random effect of the individual animal, and the other phenotypic effects of sex, percentage of Arabian blood and race distance, computed together with the genotype at <i>MSTN</i> in the statistical models, exerted a significant influence. Hence, this information is useful to improve knowledge of the genetic profile of Anglo-Arabian horses and a possible selection for better sport performance. |
topic |
myostatin racehorse Anglo-Arabian horse breed non-genetic effect |
url |
https://www.mdpi.com/2076-2615/11/4/964 |
work_keys_str_mv |
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