Assessment of the Effects of Aerobic Fitness on Cerebrovascular Function in Young Adults Using Multiple Inversion Time Arterial Spin Labeling MRI
This cross-sectional study investigated the effects of aerobic fitness on cerebrovascular function in the healthy brain. Gray matter cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) were quantified in a sample of young adults within a normal fitness range. Based on existing Transcrania...
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doaj-984b0dcdd6e1463aad3deb583a7bbc672020-11-25T02:37:48ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-04-011110.3389/fphys.2020.00360497655Assessment of the Effects of Aerobic Fitness on Cerebrovascular Function in Young Adults Using Multiple Inversion Time Arterial Spin Labeling MRICatherine Foster0Jessica J. Steventon1Jessica J. Steventon2Daniel Helme3Valentina Tomassini4Valentina Tomassini5Valentina Tomassini6Valentina Tomassini7Richard G. Wise8Richard G. Wise9Richard G. Wise10Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United KingdomCardiff University Brain Research Imaging Centre (CUBRIC), School of Physics and Astronomy, Cardiff University, Cardiff, United KingdomNeuroscience and Mental Health Research Institute (NMHRI), School of Medicine, Cardiff University, Cardiff, United KingdomDepartment of Anaesthetics and Intensive Care Medicine, Cardiff University School of Medicine, Cardiff, United KingdomCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United KingdomDivision of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University, Cardiff, United KingdomDepartment of Neuroscience, Imaging and Clinical Sciences, “G. D’Annunzio University” of Chieti-Pescara, Chieti, ItalyInstitute for Advanced Biomedical Technologies (ITAB), “G. D’Annunzio University” of Chieti-Pescara, Chieti, ItalyCardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United KingdomDepartment of Neuroscience, Imaging and Clinical Sciences, “G. D’Annunzio University” of Chieti-Pescara, Chieti, ItalyInstitute for Advanced Biomedical Technologies (ITAB), “G. D’Annunzio University” of Chieti-Pescara, Chieti, ItalyThis cross-sectional study investigated the effects of aerobic fitness on cerebrovascular function in the healthy brain. Gray matter cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) were quantified in a sample of young adults within a normal fitness range. Based on existing Transcranial Doppler ultrasound and fMRI evidence, we predicted a positive relationship between fitness and resting gray matter CBF and CVR. Exploratory hypotheses that higher V.O2peak would be associated with higher GM volume and cognitive performance were also investigated. 20 adults underwent a V.O2peak test and a battery of cognitive tests. All subjects also underwent an MRI scan where multiple inversion time (MTI) pulsed arterial spin labeling (PASL) was used to quantify resting CBF and CVR to 5% CO2. Region of interest analysis showed a non-significant inverse correlation between whole-brain gray matter CBF and V.O2peak; r = −0.4, p = 0.08, corrected p (p′) = 0.16 and a significant positive correlation between V.O2peak and whole-brain averaged gray matter CVR; r = 0.62, p = 0.003, p′ = 0.006. Voxel-wise analysis revealed a significant inverse association between V.O2peak and resting CBF in the left and right thalamus, brainstem, right lateral occipital cortex, left intra-calcarine cortex and cerebellum. The results of this study suggest that aerobic fitness is associated with lower baseline CBF and greater CVR in young adults.https://www.frontiersin.org/article/10.3389/fphys.2020.00360/fullarterial spin labelingcerebral blood flowcerebral hemodynamicscerebrovascular reactivityexercise |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Catherine Foster Jessica J. Steventon Jessica J. Steventon Daniel Helme Valentina Tomassini Valentina Tomassini Valentina Tomassini Valentina Tomassini Richard G. Wise Richard G. Wise Richard G. Wise |
spellingShingle |
Catherine Foster Jessica J. Steventon Jessica J. Steventon Daniel Helme Valentina Tomassini Valentina Tomassini Valentina Tomassini Valentina Tomassini Richard G. Wise Richard G. Wise Richard G. Wise Assessment of the Effects of Aerobic Fitness on Cerebrovascular Function in Young Adults Using Multiple Inversion Time Arterial Spin Labeling MRI Frontiers in Physiology arterial spin labeling cerebral blood flow cerebral hemodynamics cerebrovascular reactivity exercise |
author_facet |
Catherine Foster Jessica J. Steventon Jessica J. Steventon Daniel Helme Valentina Tomassini Valentina Tomassini Valentina Tomassini Valentina Tomassini Richard G. Wise Richard G. Wise Richard G. Wise |
author_sort |
Catherine Foster |
title |
Assessment of the Effects of Aerobic Fitness on Cerebrovascular Function in Young Adults Using Multiple Inversion Time Arterial Spin Labeling MRI |
title_short |
Assessment of the Effects of Aerobic Fitness on Cerebrovascular Function in Young Adults Using Multiple Inversion Time Arterial Spin Labeling MRI |
title_full |
Assessment of the Effects of Aerobic Fitness on Cerebrovascular Function in Young Adults Using Multiple Inversion Time Arterial Spin Labeling MRI |
title_fullStr |
Assessment of the Effects of Aerobic Fitness on Cerebrovascular Function in Young Adults Using Multiple Inversion Time Arterial Spin Labeling MRI |
title_full_unstemmed |
Assessment of the Effects of Aerobic Fitness on Cerebrovascular Function in Young Adults Using Multiple Inversion Time Arterial Spin Labeling MRI |
title_sort |
assessment of the effects of aerobic fitness on cerebrovascular function in young adults using multiple inversion time arterial spin labeling mri |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2020-04-01 |
description |
This cross-sectional study investigated the effects of aerobic fitness on cerebrovascular function in the healthy brain. Gray matter cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) were quantified in a sample of young adults within a normal fitness range. Based on existing Transcranial Doppler ultrasound and fMRI evidence, we predicted a positive relationship between fitness and resting gray matter CBF and CVR. Exploratory hypotheses that higher V.O2peak would be associated with higher GM volume and cognitive performance were also investigated. 20 adults underwent a V.O2peak test and a battery of cognitive tests. All subjects also underwent an MRI scan where multiple inversion time (MTI) pulsed arterial spin labeling (PASL) was used to quantify resting CBF and CVR to 5% CO2. Region of interest analysis showed a non-significant inverse correlation between whole-brain gray matter CBF and V.O2peak; r = −0.4, p = 0.08, corrected p (p′) = 0.16 and a significant positive correlation between V.O2peak and whole-brain averaged gray matter CVR; r = 0.62, p = 0.003, p′ = 0.006. Voxel-wise analysis revealed a significant inverse association between V.O2peak and resting CBF in the left and right thalamus, brainstem, right lateral occipital cortex, left intra-calcarine cortex and cerebellum. The results of this study suggest that aerobic fitness is associated with lower baseline CBF and greater CVR in young adults. |
topic |
arterial spin labeling cerebral blood flow cerebral hemodynamics cerebrovascular reactivity exercise |
url |
https://www.frontiersin.org/article/10.3389/fphys.2020.00360/full |
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