The Functional Roles of the MDM2 Splice Variants P2-MDM2-10 and MDM2-∆5 in Breast Cancer Cells

The Functional Roles of the MDM2 Splice Variants P2-MDM2-10 and MDM2-∆5 in Breast Cancer Cells

BACKGROUND: MDM2 is a negative regulator of p53 and is upregulated in numerous human cancers. While different MDM2 splice variants have been observed in both normal tissues and malignant cells, their functions are poorly understood. METHODS: We evaluated the effect of MDM2 splice variants by overexp...

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Bibliographic Details
Main Authors: Johanna Huun, Liv B. Gansmo, Bård Mannsåker, Gjertrud T. Iversen, Jan Sommerfelt-Pettersen, Jan Inge Øvrebø, Per E. Lønning, Stian Knappskog
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523317302346

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