Human Somatostatin SST<sub>4</sub> Receptor Transgenic Mice: Construction and Brain Expression Pattern Characterization

Human Somatostatin SST<sub>4</sub> Receptor Transgenic Mice: Construction and Brain Expression Pattern Characterization

Somatostatin receptor subtype 4 (SST<sub>4</sub>) has been shown to mediate analgesic, antidepressant and anti-inflammatory functions without endocrine actions; therefore, it is proposed to be a novel target for drug development. To overcome the species differences of SST<sub>4<...

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Bibliographic Details
Main Authors: Balázs Nemes, Kata Bölcskei, Angéla Kecskés, Viktória Kormos, Balázs Gaszner, Timea Aczél, Dániel Hegedüs, Erika Pintér, Zsuzsanna Helyes, Zoltán Sándor
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
somatostatin
<i>Sstr4</i> KO mice
<i>SSTR4</i> humanized mice
PiggyBac (PB) transposon vector
ligation-mediated PCR
RNAscope in situ hybridization
Online Access:https://www.mdpi.com/1422-0067/22/7/3758

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