Familial Mediterranean Fever With Complete Symptomatic Remission During Pregnancy

• Main Authors: Kwang Taek Kim, Hyun Joo Jang, Jae Eun Lee, Mi Kang Kim, Jun Jae Yoo, Gye Yeon Lee, Sea Hyub Kae, Jin Lee
• Format: Article
• Language: English
• Published: Korean Association for the Study of Intestinal Diseases 2015-07-01
• Series: Intestinal Research
• Subjects: Familial Mediterranean fever; Periodic fever syndrome; gene; Pregnancy
• Online Access: http://www.irjournal.org/upload/pdf/ir-13-287.pdf
• ISSN: 1598-9100; 2288-1956

Familial Mediterranean fever (FMF) is an inherited autosomal recessive disorder, ethnically restricted and commonly found among populations surrounding the Mediterranean Sea. FMF is the most prevalent autoinflammatory disease; is characterized by recurrent, self-limited episodes of fever with serositis; and is caused by Mediterranean fever gene (MEFV) mutations on chromosome 16. We describe a case of adult-onset FMF with complete symptomatic remission during pregnancy, without the use of colchicine. A 25-year-old woman had presented with periodic fever, abdominal pain, and vomiting since she was 21. Her abdominal computed tomography scan showed intestinal nonrotation. She underwent exploratory laparotomy and appendectomy for her symptoms 1 year prior. She had a symptom-free pregnancy period, but abdominal pain and fever recurred after delivery. Mutation analysis of the MEFV gene revealed two point mutations (p.Leu110Pro and p.Glu148Gln). We report an adult female patient with FMF in Korea with complete symptomatic remission during pregnancy.