Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference
Physiological studies documented highly specific corticofugal modulations making subcortical centers focus processing on sounds that the auditory cortex (AC) has experienced to be important. Here, we show the effects of focal conditioning (FC) of the primary auditory cortex (FCAI) on auditory brains...
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2019-08-01
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doaj-98646dbb417c4a3c8c84499ddcdb69212020-11-24T22:02:35ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372019-08-011310.3389/fnsys.2019.00039477332Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical PreferenceXiuping Liu0Oliver Zhang1Amber Chen2Kaili Hu3Günter Ehret4Jun Yan5Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaInstitute of Neurobiology, University of Ulm, Ulm, GermanyDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaPhysiological studies documented highly specific corticofugal modulations making subcortical centers focus processing on sounds that the auditory cortex (AC) has experienced to be important. Here, we show the effects of focal conditioning (FC) of the primary auditory cortex (FCAI) on auditory brainstem response (ABR) amplitudes and latencies in house mice. FCAI significantly increased ABR peak amplitudes (peaks I–V), decreased thresholds, and shortened peak latencies in responses to the frequency tuned by conditioned cortical neurons. The amounts of peak amplitude increases and latency decreases were specific for each processing level up to the auditory midbrain. The data provide new insights into possible corticofugal modulation of inner hair cell synapses and new corticofugal effects as neuronal enhancement of processing in the superior olivary complex (SOC) and lateral lemniscus (LL). Thus, our comprehensive ABR approach confirms the role of the AC as instructor of lower auditory levels and extends this role specifically to the cochlea, SOC, and LL. The whole pathway from the cochlea to the inferior colliculus appears, in a common mode, instructed in a very similar way.https://www.frontiersin.org/article/10.3389/fnsys.2019.00039/fullABRcochlear enhancementcorticofugal modulationdescending auditory systemfocal conditioningfrequency-specific enhancement |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiuping Liu Oliver Zhang Amber Chen Kaili Hu Günter Ehret Jun Yan |
spellingShingle |
Xiuping Liu Oliver Zhang Amber Chen Kaili Hu Günter Ehret Jun Yan Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference Frontiers in Systems Neuroscience ABR cochlear enhancement corticofugal modulation descending auditory system focal conditioning frequency-specific enhancement |
author_facet |
Xiuping Liu Oliver Zhang Amber Chen Kaili Hu Günter Ehret Jun Yan |
author_sort |
Xiuping Liu |
title |
Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference |
title_short |
Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference |
title_full |
Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference |
title_fullStr |
Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference |
title_full_unstemmed |
Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference |
title_sort |
corticofugal augmentation of the auditory brainstem response with respect to cortical preference |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Systems Neuroscience |
issn |
1662-5137 |
publishDate |
2019-08-01 |
description |
Physiological studies documented highly specific corticofugal modulations making subcortical centers focus processing on sounds that the auditory cortex (AC) has experienced to be important. Here, we show the effects of focal conditioning (FC) of the primary auditory cortex (FCAI) on auditory brainstem response (ABR) amplitudes and latencies in house mice. FCAI significantly increased ABR peak amplitudes (peaks I–V), decreased thresholds, and shortened peak latencies in responses to the frequency tuned by conditioned cortical neurons. The amounts of peak amplitude increases and latency decreases were specific for each processing level up to the auditory midbrain. The data provide new insights into possible corticofugal modulation of inner hair cell synapses and new corticofugal effects as neuronal enhancement of processing in the superior olivary complex (SOC) and lateral lemniscus (LL). Thus, our comprehensive ABR approach confirms the role of the AC as instructor of lower auditory levels and extends this role specifically to the cochlea, SOC, and LL. The whole pathway from the cochlea to the inferior colliculus appears, in a common mode, instructed in a very similar way. |
topic |
ABR cochlear enhancement corticofugal modulation descending auditory system focal conditioning frequency-specific enhancement |
url |
https://www.frontiersin.org/article/10.3389/fnsys.2019.00039/full |
work_keys_str_mv |
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