Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference

Physiological studies documented highly specific corticofugal modulations making subcortical centers focus processing on sounds that the auditory cortex (AC) has experienced to be important. Here, we show the effects of focal conditioning (FC) of the primary auditory cortex (FCAI) on auditory brains...

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Main Authors: Xiuping Liu, Oliver Zhang, Amber Chen, Kaili Hu, Günter Ehret, Jun Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Systems Neuroscience
Subjects:
ABR
Online Access:https://www.frontiersin.org/article/10.3389/fnsys.2019.00039/full
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spelling doaj-98646dbb417c4a3c8c84499ddcdb69212020-11-24T22:02:35ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372019-08-011310.3389/fnsys.2019.00039477332Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical PreferenceXiuping Liu0Oliver Zhang1Amber Chen2Kaili Hu3Günter Ehret4Jun Yan5Department of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaInstitute of Neurobiology, University of Ulm, Ulm, GermanyDepartment of Physiology and Pharmacology, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, CanadaPhysiological studies documented highly specific corticofugal modulations making subcortical centers focus processing on sounds that the auditory cortex (AC) has experienced to be important. Here, we show the effects of focal conditioning (FC) of the primary auditory cortex (FCAI) on auditory brainstem response (ABR) amplitudes and latencies in house mice. FCAI significantly increased ABR peak amplitudes (peaks I–V), decreased thresholds, and shortened peak latencies in responses to the frequency tuned by conditioned cortical neurons. The amounts of peak amplitude increases and latency decreases were specific for each processing level up to the auditory midbrain. The data provide new insights into possible corticofugal modulation of inner hair cell synapses and new corticofugal effects as neuronal enhancement of processing in the superior olivary complex (SOC) and lateral lemniscus (LL). Thus, our comprehensive ABR approach confirms the role of the AC as instructor of lower auditory levels and extends this role specifically to the cochlea, SOC, and LL. The whole pathway from the cochlea to the inferior colliculus appears, in a common mode, instructed in a very similar way.https://www.frontiersin.org/article/10.3389/fnsys.2019.00039/fullABRcochlear enhancementcorticofugal modulationdescending auditory systemfocal conditioningfrequency-specific enhancement
collection DOAJ
language English
format Article
sources DOAJ
author Xiuping Liu
Oliver Zhang
Amber Chen
Kaili Hu
Günter Ehret
Jun Yan
spellingShingle Xiuping Liu
Oliver Zhang
Amber Chen
Kaili Hu
Günter Ehret
Jun Yan
Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference
Frontiers in Systems Neuroscience
ABR
cochlear enhancement
corticofugal modulation
descending auditory system
focal conditioning
frequency-specific enhancement
author_facet Xiuping Liu
Oliver Zhang
Amber Chen
Kaili Hu
Günter Ehret
Jun Yan
author_sort Xiuping Liu
title Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference
title_short Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference
title_full Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference
title_fullStr Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference
title_full_unstemmed Corticofugal Augmentation of the Auditory Brainstem Response With Respect to Cortical Preference
title_sort corticofugal augmentation of the auditory brainstem response with respect to cortical preference
publisher Frontiers Media S.A.
series Frontiers in Systems Neuroscience
issn 1662-5137
publishDate 2019-08-01
description Physiological studies documented highly specific corticofugal modulations making subcortical centers focus processing on sounds that the auditory cortex (AC) has experienced to be important. Here, we show the effects of focal conditioning (FC) of the primary auditory cortex (FCAI) on auditory brainstem response (ABR) amplitudes and latencies in house mice. FCAI significantly increased ABR peak amplitudes (peaks I–V), decreased thresholds, and shortened peak latencies in responses to the frequency tuned by conditioned cortical neurons. The amounts of peak amplitude increases and latency decreases were specific for each processing level up to the auditory midbrain. The data provide new insights into possible corticofugal modulation of inner hair cell synapses and new corticofugal effects as neuronal enhancement of processing in the superior olivary complex (SOC) and lateral lemniscus (LL). Thus, our comprehensive ABR approach confirms the role of the AC as instructor of lower auditory levels and extends this role specifically to the cochlea, SOC, and LL. The whole pathway from the cochlea to the inferior colliculus appears, in a common mode, instructed in a very similar way.
topic ABR
cochlear enhancement
corticofugal modulation
descending auditory system
focal conditioning
frequency-specific enhancement
url https://www.frontiersin.org/article/10.3389/fnsys.2019.00039/full
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