Therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in rats
Objective(s): The current study was designed to investigate the therapeutic and protective effects of montelukast (ML) against doxorubicin (DOX)-induced acute kidney damage in rats.Materials and Methods: Thirty-five Wistar albino female rats were randomly divided into 5 groups as follows: Group I: C...
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doaj-986ad838f20d471597209cd3cc5c1a192020-11-25T01:00:17ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences 2008-38662008-38742019-04-0122440741110.22038/ijbms.2019.33493.799612288Therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in ratsEvren Kose0Fatih Oguz1Nigar Vardi2Mehmet Sarihan3Ali Beytur4Aytac yucel5Alaadin Polat6Nihat Ekinci7Department of Anatomy, School of Medicine, Inonu University, Malatya, TurkeyDepartment of Urology, School of Medicine, Inonu University, Malatya, TurkeyDepartment of Histology-Embryology, School of Medicine, Inonu University, Malatya, TurkeyDepartment of Emergency, School of Medicine, Inonu University, Malatya, TurkeyDepartment of Urology, School of Medicine, Inonu University, Malatya, TurkeyDepartment of Anesthesiology and Reanimation, School of Medicine, Inonu University, Malatya, TurkeyDepartment of Physiology, School of Medicine, Inonu University, Malatya, TurkeyDepartment of Anatomy, School of Medicine, Erciyes University, Kayseri, TurkeyObjective(s): The current study was designed to investigate the therapeutic and protective effects of montelukast (ML) against doxorubicin (DOX)-induced acute kidney damage in rats.Materials and Methods: Thirty-five Wistar albino female rats were randomly divided into 5 groups as follows: Group I: Control; Group II: Control+ML; Group III: DOX; Group IV: DOX+ML; Group V: ML+DOX. At the end of the experiment, the kidney tissues of rats were collected. Thiobarbituric acid reactive substance (TBARS), reduced glutathione, superoxide dismutase (SOD), and catalase levels were determined from the kidney tissues. In addition, the kidney tissues were examined histologically.Results: DOX induced a significant increase in the kidney TBARS levels, whereas SOD contents significantly decreased when compared with the control group. On the other hand, ML administration before and after DOX injection caused significant decreases in TBARS production and also increases in SOD levels. Histologically, the most remarkable damage was glomerulosclerosis and tubular changes in the DOX group. Moreover, marked tubular necrosis and swelling in tubular epithelial cells were observed in this group. Contrarily, although glomerulosclerosis was recognized as alleviated also in both DOX+ML and ML+DOX groups, the lesions did not completely ameliorate. However, treatment with ML after DOX injection was more effective than treatment with ML before DOX injection with respect to the protection of tubular structures. Conclusion: It was determined that ML treatment after DOX injection caused therapeutic effects against DOX-induced kidney damage. Thence, ML treatment is of some clinical properties for oxidative stress damage in kidney tissues.http://ijbms.mums.ac.ir/article_12288_16f66ddf28ddbe7a76e4407324ec94af.pdfDoxorubicinHistologyKidneyLeukotrienesOxidative stressTBARS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Evren Kose Fatih Oguz Nigar Vardi Mehmet Sarihan Ali Beytur Aytac yucel Alaadin Polat Nihat Ekinci |
spellingShingle |
Evren Kose Fatih Oguz Nigar Vardi Mehmet Sarihan Ali Beytur Aytac yucel Alaadin Polat Nihat Ekinci Therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in rats Iranian Journal of Basic Medical Sciences Doxorubicin Histology Kidney Leukotrienes Oxidative stress TBARS |
author_facet |
Evren Kose Fatih Oguz Nigar Vardi Mehmet Sarihan Ali Beytur Aytac yucel Alaadin Polat Nihat Ekinci |
author_sort |
Evren Kose |
title |
Therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in rats |
title_short |
Therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in rats |
title_full |
Therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in rats |
title_fullStr |
Therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in rats |
title_full_unstemmed |
Therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in rats |
title_sort |
therapeutic and protective effects of montelukast against doxorubicin-induced acute kidney damage in rats |
publisher |
Mashhad University of Medical Sciences |
series |
Iranian Journal of Basic Medical Sciences |
issn |
2008-3866 2008-3874 |
publishDate |
2019-04-01 |
description |
Objective(s): The current study was designed to investigate the therapeutic and protective effects of montelukast (ML) against doxorubicin (DOX)-induced acute kidney damage in rats.Materials and Methods: Thirty-five Wistar albino female rats were randomly divided into 5 groups as follows: Group I: Control; Group II: Control+ML; Group III: DOX; Group IV: DOX+ML; Group V: ML+DOX. At the end of the experiment, the kidney tissues of rats were collected. Thiobarbituric acid reactive substance (TBARS), reduced glutathione, superoxide dismutase (SOD), and catalase levels were determined from the kidney tissues. In addition, the kidney tissues were examined histologically.Results: DOX induced a significant increase in the kidney TBARS levels, whereas SOD contents significantly decreased when compared with the control group. On the other hand, ML administration before and after DOX injection caused significant decreases in TBARS production and also increases in SOD levels. Histologically, the most remarkable damage was glomerulosclerosis and tubular changes in the DOX group. Moreover, marked tubular necrosis and swelling in tubular epithelial cells were observed in this group. Contrarily, although glomerulosclerosis was recognized as alleviated also in both DOX+ML and ML+DOX groups, the lesions did not completely ameliorate. However, treatment with ML after DOX injection was more effective than treatment with ML before DOX injection with respect to the protection of tubular structures. Conclusion: It was determined that ML treatment after DOX injection caused therapeutic effects against DOX-induced kidney damage. Thence, ML treatment is of some clinical properties for oxidative stress damage in kidney tissues. |
topic |
Doxorubicin Histology Kidney Leukotrienes Oxidative stress TBARS |
url |
http://ijbms.mums.ac.ir/article_12288_16f66ddf28ddbe7a76e4407324ec94af.pdf |
work_keys_str_mv |
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