MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer
The identification of exosomes, their link to multivesicular bodies and their potential role as a messenger vehicle between cancer and healthy cells opens up a new approach to the study of intercellular signaling. Furthermore, the fact that their main cargo is likely to be microRNAs (miRNAs) provide...
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MDPI AG
2019-03-01
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Online Access: | https://www.mdpi.com/2311-553X/5/1/28 |
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doaj-9874680320ba47f6bed52f0a5a8477912020-11-25T02:31:45ZengMDPI AGNon-Coding RNA2311-553X2019-03-01512810.3390/ncrna5010028ncrna5010028MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in CancerHeidi Schwarzenbach0Peter B. Gahan1Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyFondazione “Enrico Puccinelli” Onlus, 06126 Perugia, ItalyThe identification of exosomes, their link to multivesicular bodies and their potential role as a messenger vehicle between cancer and healthy cells opens up a new approach to the study of intercellular signaling. Furthermore, the fact that their main cargo is likely to be microRNAs (miRNAs) provides the possibility of the transfer of such molecules to control activities in the recipient cells. This review concerns a brief overview of the biogenesis of both exosomes and miRNAs together with the movement of such structures between cells. The possible roles of miRNAs in the development and progression of breast, ovarian and prostate cancers are discussed.https://www.mdpi.com/2311-553X/5/1/28microRNA biogenesismicroRNA functionsmicroRNA pathwaysexosome biogenesisexosome functionsexosomal signalingbreast cancerepithelialovarian cancerprostate cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Heidi Schwarzenbach Peter B. Gahan |
spellingShingle |
Heidi Schwarzenbach Peter B. Gahan MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer Non-Coding RNA microRNA biogenesis microRNA functions microRNA pathways exosome biogenesis exosome functions exosomal signaling breast cancer epithelial ovarian cancer prostate cancer |
author_facet |
Heidi Schwarzenbach Peter B. Gahan |
author_sort |
Heidi Schwarzenbach |
title |
MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer |
title_short |
MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer |
title_full |
MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer |
title_fullStr |
MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer |
title_full_unstemmed |
MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer |
title_sort |
microrna shuttle from cell-to-cell by exosomes and its impact in cancer |
publisher |
MDPI AG |
series |
Non-Coding RNA |
issn |
2311-553X |
publishDate |
2019-03-01 |
description |
The identification of exosomes, their link to multivesicular bodies and their potential role as a messenger vehicle between cancer and healthy cells opens up a new approach to the study of intercellular signaling. Furthermore, the fact that their main cargo is likely to be microRNAs (miRNAs) provides the possibility of the transfer of such molecules to control activities in the recipient cells. This review concerns a brief overview of the biogenesis of both exosomes and miRNAs together with the movement of such structures between cells. The possible roles of miRNAs in the development and progression of breast, ovarian and prostate cancers are discussed. |
topic |
microRNA biogenesis microRNA functions microRNA pathways exosome biogenesis exosome functions exosomal signaling breast cancer epithelial ovarian cancer prostate cancer |
url |
https://www.mdpi.com/2311-553X/5/1/28 |
work_keys_str_mv |
AT heidischwarzenbach micrornashuttlefromcelltocellbyexosomesanditsimpactincancer AT peterbgahan micrornashuttlefromcelltocellbyexosomesanditsimpactincancer |
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1724822264878202880 |