MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer

The identification of exosomes, their link to multivesicular bodies and their potential role as a messenger vehicle between cancer and healthy cells opens up a new approach to the study of intercellular signaling. Furthermore, the fact that their main cargo is likely to be microRNAs (miRNAs) provide...

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Main Authors: Heidi Schwarzenbach, Peter B. Gahan
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Non-Coding RNA
Subjects:
Online Access:https://www.mdpi.com/2311-553X/5/1/28
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spelling doaj-9874680320ba47f6bed52f0a5a8477912020-11-25T02:31:45ZengMDPI AGNon-Coding RNA2311-553X2019-03-01512810.3390/ncrna5010028ncrna5010028MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in CancerHeidi Schwarzenbach0Peter B. Gahan1Department of Tumor Biology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, GermanyFondazione “Enrico Puccinelli” Onlus, 06126 Perugia, ItalyThe identification of exosomes, their link to multivesicular bodies and their potential role as a messenger vehicle between cancer and healthy cells opens up a new approach to the study of intercellular signaling. Furthermore, the fact that their main cargo is likely to be microRNAs (miRNAs) provides the possibility of the transfer of such molecules to control activities in the recipient cells. This review concerns a brief overview of the biogenesis of both exosomes and miRNAs together with the movement of such structures between cells. The possible roles of miRNAs in the development and progression of breast, ovarian and prostate cancers are discussed.https://www.mdpi.com/2311-553X/5/1/28microRNA biogenesismicroRNA functionsmicroRNA pathwaysexosome biogenesisexosome functionsexosomal signalingbreast cancerepithelialovarian cancerprostate cancer
collection DOAJ
language English
format Article
sources DOAJ
author Heidi Schwarzenbach
Peter B. Gahan
spellingShingle Heidi Schwarzenbach
Peter B. Gahan
MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer
Non-Coding RNA
microRNA biogenesis
microRNA functions
microRNA pathways
exosome biogenesis
exosome functions
exosomal signaling
breast cancer
epithelial
ovarian cancer
prostate cancer
author_facet Heidi Schwarzenbach
Peter B. Gahan
author_sort Heidi Schwarzenbach
title MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer
title_short MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer
title_full MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer
title_fullStr MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer
title_full_unstemmed MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer
title_sort microrna shuttle from cell-to-cell by exosomes and its impact in cancer
publisher MDPI AG
series Non-Coding RNA
issn 2311-553X
publishDate 2019-03-01
description The identification of exosomes, their link to multivesicular bodies and their potential role as a messenger vehicle between cancer and healthy cells opens up a new approach to the study of intercellular signaling. Furthermore, the fact that their main cargo is likely to be microRNAs (miRNAs) provides the possibility of the transfer of such molecules to control activities in the recipient cells. This review concerns a brief overview of the biogenesis of both exosomes and miRNAs together with the movement of such structures between cells. The possible roles of miRNAs in the development and progression of breast, ovarian and prostate cancers are discussed.
topic microRNA biogenesis
microRNA functions
microRNA pathways
exosome biogenesis
exosome functions
exosomal signaling
breast cancer
epithelial
ovarian cancer
prostate cancer
url https://www.mdpi.com/2311-553X/5/1/28
work_keys_str_mv AT heidischwarzenbach micrornashuttlefromcelltocellbyexosomesanditsimpactincancer
AT peterbgahan micrornashuttlefromcelltocellbyexosomesanditsimpactincancer
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