Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents

By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl- or heteroarylboronic acids, new aziridines could be obtain...

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Main Authors:	Arianna Giovine, Marilena Muraglia, Marco Antonio Florio, Antonio Rosato, Filomena Corbo, Carlo Franchini, Biagia Musio, Leonardo Degennaro, Renzo Luisi
Format:	Article
Language:	English
Published:	MDPI AG 2014-08-01
Series:	Molecules
Subjects:	aziridines boron compounds Suzuki-Miyaura palladium coupling antibiotics
Online Access:	http://www.mdpi.com/1420-3049/19/8/11505

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spelling	doaj-987bfcdb99f34a30a71561822cf81c172020-11-24T22:35:22ZengMDPI AGMolecules1420-30492014-08-01198115051151910.3390/molecules190811505molecules190811505Synthesis of Functionalized Arylaziridines as Potential Antimicrobial AgentsArianna Giovine0Marilena Muraglia1Marco Antonio Florio2Antonio Rosato3Filomena Corbo4Carlo Franchini5Biagia Musio6Leonardo Degennaro7Renzo Luisi8Department of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, ItalyDepartment of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, ItalyDepartment of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, ItalyDepartment of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, ItalyDepartment of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, ItalyDepartment of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, ItalyDepartment of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, ItalyDepartment of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, ItalyDepartment of Pharmacy-Drug Science, University of Bari "A. Moro", Via E.Orabona 4, Bari 70125, ItalyBy using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl- or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included.http://www.mdpi.com/1420-3049/19/8/11505aziridinesboron compoundsSuzuki-Miyaurapalladium couplingantibiotics
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Arianna Giovine Marilena Muraglia Marco Antonio Florio Antonio Rosato Filomena Corbo Carlo Franchini Biagia Musio Leonardo Degennaro Renzo Luisi
spellingShingle	Arianna Giovine Marilena Muraglia Marco Antonio Florio Antonio Rosato Filomena Corbo Carlo Franchini Biagia Musio Leonardo Degennaro Renzo Luisi Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents Molecules aziridines boron compounds Suzuki-Miyaura palladium coupling antibiotics
author_facet	Arianna Giovine Marilena Muraglia Marco Antonio Florio Antonio Rosato Filomena Corbo Carlo Franchini Biagia Musio Leonardo Degennaro Renzo Luisi
author_sort	Arianna Giovine
title	Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents
title_short	Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents
title_full	Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents
title_fullStr	Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents
title_full_unstemmed	Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents
title_sort	synthesis of functionalized arylaziridines as potential antimicrobial agents
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2014-08-01
description	By using the Suzuki-Miyaura protocol, a simple straightforward synthesis of functionalized 2-arylaziridines has been developed. By means of this synthetic strategy from readily available ortho-, meta- and para-bromophenylaziridines and aryl- or heteroarylboronic acids, new aziridines could be obtained. The cross-coupling reactions occurred without ring opening of the three membered ring. Preliminary results on the antimicrobial activity of the heterosubstituted biaryl compounds have been also included.
topic	aziridines boron compounds Suzuki-Miyaura palladium coupling antibiotics
url	http://www.mdpi.com/1420-3049/19/8/11505
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Synthesis of Functionalized Arylaziridines as Potential Antimicrobial Agents

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